This volume discusses prools that cover synthesis, screening by selection, and analysis of DNA-encoded chemical libraries (DEL). Chapters in this book focus on methods used to practice DEL technology and include solution phase library synthesis using a variety of chemistries; DNA encoding of chemical structure; design, preparation and analysis of target proteins and tool compounds; screening of soluble protein targets by affinity selection; DEL qPCR, preparative PCR and DNA sequence analysis; computational methods used to analyze selections and choose compounds for resynthesis; and analysis of hit compounds. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory prools, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and comprehensive, DNA-Encoded Chemical Libraries:Methods and Prools is a valuable resource for scientists interested in DEL technology for drug discovery, and will contribute to the continued advancement in this important field.
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Cutting-edge and comprehensive, DNA-Encoded Chemical Libraries:Methods and Prools is a valuable resource for scientists interested in DEL technology for drug discovery, and will contribute to the continued advancement in this important field.
DNA-Encoded Chemical Libraries: Methods and Protocols
This volume discusses prools that cover synthesis, screening by selection, and analysis of DNA-encoded chemical libraries (DEL). Chapters in this book focus on methods used to practice DEL technology and include solution phase library synthesis using a variety of chemistries; DNA encoding of chemical structure; design, preparation and analysis of target proteins and tool compounds; screening of soluble protein targets by affinity selection; DEL qPCR, preparative PCR and DNA sequence analysis; computational methods used to analyze selections and choose compounds for resynthesis; and analysis of hit compounds. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory prools, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and comprehensive, DNA-Encoded Chemical Libraries:Methods and Prools is a valuable resource for scientists interested in DEL technology for drug discovery, and will contribute to the continued advancement in this important field.
Cutting-edge and comprehensive, DNA-Encoded Chemical Libraries:Methods and Prools is a valuable resource for scientists interested in DEL technology for drug discovery, and will contribute to the continued advancement in this important field.
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DNA-Encoded Chemical Libraries: Methods and Protocols
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DNA-Encoded Chemical Libraries: Methods and Protocols
226Paperback(1st ed. 2022)
$119.99
119.99
In Stock
Product Details
ISBN-13: | 9781071625477 |
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Publisher: | Springer US |
Publication date: | 09/11/2023 |
Series: | Methods in Molecular Biology , #2541 |
Edition description: | 1st ed. 2022 |
Pages: | 226 |
Product dimensions: | 7.01(w) x 10.00(h) x (d) |
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