Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part A

by Elsevier Science

Overview

This new volume of Advances in Pharmacology presents the diversity and functions of GABA Receptors. The volume looks at research performed in the past 20 years which has revealed specific physiological and pharmacological functions of individual GABA_A receptor subtypes, providing novel opportunities for drug development.

• Contributions from the best authors in the field
• An essential resource for pharmacologists, immunologists, and biochemists

Product Details

ISBN-13:	9780128026922
Publisher:	Elsevier Science
Publication date:	01/12/2015
Series:	ISSN , #72
Sold by:	Barnes & Noble
Format:	eBook
Pages:	282
File size:	8 MB

About the Author

Dr. Rudolph is Director of the Laboratory of Genetic Neuropharmacoloy at McLean Hospital and Professor of Psychiatry at Harvard Medical School. He studied medicine and completed a research thesis on G proteins at the Freie Universitat Berlin, Germany. After postdoctoral training at Baylor College of Medicine in Houston, Texas, where he developed a mouse model of inflammatory bowel disease and colon cancer, he moved to the Institute of Pharmacology and Toxicology of the University of Zurich to work on GABAA receptors. There, he developed different lines of knock-in mice in which diazepam-sensitive GABAA receptor subtypes were rendered insensitive to diazepam by a histidine to arginine point mutation. Studying these mice enables researchers to uncover unique functional roles of GABAA receptor subtypes. In 2005, he joined McLean Hospital in Belmont, MA, and Harvard Medical School, where his research group is elucidating the functions of GABAA receptor subtypes in defined neuronal populations.

Table of Contents

1. The Legacy of the Benzodiazepine Receptor: From Flumazenil to Enhancing Cognition in Down Syndrome and Social Interaction in Autism
Hanns Möhler
2. Behavioral Functions of GABA_A  Receptor Subtypes – the Zurich Experience
Florence Crestani and Uwe Rudolph
3. Allosteric Modulation of GABA_A  Receptors via Multiple Drug Binding Sites
Werner Sieghart
4. Regulation of GABA_ARs by Phosphorylation
Yasuko Nakamura, Laura M. Darnieder, Tarek Z. Deeb and Stephen J. Moss
5. Endozepines
Zoya Farzampour, Richard J. Reimer and John Huguenard
6. Inhibitory Neurosteroids and the GABA_A  Receptor
Sandra Seljeset, Duncan Laverty and Trevor G Smart
7. Interactions of Flavonoids with Ionotropic GABA_A  Receptors
Jane R Hanrahan, Mary Chebib and Graham A R Johnston
8. GABA_A  Receptor Partial Agonists and Antagonists: Structure, Binding Mode, and Pharmacology
Jacob Krall, Thomas Balle, Niels Krogsgaard-Larsen, Troels E. Sørensen, Povl Krogsgaard-Larsen, Uffe Kristiansen and Bente Frølund
9. Closing the Gap between the Molecular and Systemic Actions of Anesthetic Agents
Bernd Antkowiak

Editorial Reviews

Praise for the Series: "...recommended not only to pharmacologists but also to all those in related disciplines" —Nature

From the Publisher