Disorders of Voluntary Muscle

by George Karpati, David Hilton-Jones (Editor), Kate Bushby (Editor), Robert C. Griggs (Editor)

Overview

This major new edition fulfils the need for a single-volume, up-to-date information resource on the etiology, pathogenesis, diagnosis and treatment of diseases of skeletal muscles, including the muscular dystrophies, mitochondrial myopathies, metabolic myopathies, ion channel disorders, and dysimmune myopathies. As background to the clinical coverage, relevant information on advances in molecular and developmental biology, immunopathology, mitochondrial biology, ion-channel dynamics, cell membrane and signal transduction science, and imaging technology is summarized. Combining essential new knowledge with the fundamentals of history-taking and clinical examination, this extensively illustrated book will continue to be the mainstay for practising physicians and biomedical scientists concerned with muscle disease. Regular updates on the clinical and basic science aspects of muscle disease - written mainly by rising stars of myology - will be published on an accompanying website.

Product Details

ISBN-13:	9780511739170
Publisher:	Cambridge University Press
Publication date:	01/21/2010
Sold by:	Barnes & Noble
Format:	eBook
File size:	46 MB
Note:	This product may take a few minutes to download.

About the Author

George Karpati is Isaac Walton Killam Chair and Professor at the Department of Neurology and Neurosurgery, McGill University, and the Montreal Neurological Institute, Montreal, Quebec, Canada.
David Hilton-Jones is Clinical Director of the Muscular Dystrophy Campaign Muscle and Nerve Centre, John Radcliffe Hospital, Oxford, UK.
Kate Bushby is Professor of Neuromuscular Genetics at the Institute of Human Genetics, International Centre for Life, Newcastle upon Tyne, UK.
Robert C. Griggs is Professor of Neurology, Medicine, Pediatrics, Pathology and Laboratory Medicine at the Department of Neurology, University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital, Rochester, New York, USA. He is also Chair of the Muscle Study Group Executive Committee.

Table of Contents

Preface; Foreword John Walton; Part I. The Scientific Basis of Muscle Disease: 1. Structure and function of muscle fibres and motor units Mary Kay Floeter; 2. Myogenic precursor cells Miranda D. Grounds and Frederic Relaix; 3. Biochemical and molecular basis of muscle disease Susan Brown and Cecilia Jimenez-Mallebera; Part II. Investigation of Muscle Disease: 4. Electromyography and related techniques Eric Logigian and Emma Ciafaloni; 5. Histopathology and immunoanalysis of muscle Caroline A. Sewry and Maria J. Molnar; 6. Ultrastructural study of muscle Anders Oldfors; 7. Diagnostic imaging of muscle Eugenio Mercuri and Marianne de Visser; Part III. Description of Muscle Disease; Section 1. General Aspects: 8. The clinical assessment and a guide to classification of the myopathies David Hilton-Jones and John T. Kissel; 9. The principles of molecular therapies for muscle diseases George Karpati and Renald Gilbert; Section 2. Specific Diseases: 10. Dystrophinopathies Michael Sinnreich; 11. Muscular dystrophies presenting with proximal muscle weakness Mariz Vainzof and Kate Bushby; 12. Dystrophies and myopathies of early childhood onset Carsten G. Bönnemann and Enrico Bertini; 13. Congenital myopathies Carina Wallgren-Pettersson and Nigel G. Laing; 14. Muscle diseases with prominent muscle contractures Gisèle Bonne and Anne K. Lampe; 15. Facioscapulohumeral muscular dystrophy Shannon L. Venance and Rabi Tawil; 16. Distal myopathies Bjarne Udd; 17. Oculopharyngeal muscular dystrophy Bernard Brais; 18. Myotonic dystrophy John Day and Charles Thornton; 19. Mitochondrial myopathies and related disorders Patrick F. Chinnery and Eric A. Shoubridge; 20. Metabolic myopathies John Vissing, Stefano DiDonato and Franco Taroni; 21. Muscle ion channelopathies and related disorders Bertrand Fontaine and Michael G. Hanna; 22. Inflammatory and dysimmune myopathies Marinos C. Dalakas and George Karpati; 23. Myasthenia gravis and myasthenic syndromes [autoimmune and genetic] Amelia Evoli, Hanns Lochmüller and Violeta Mihaylova; 24. Endocrine and toxic myopathies Zohar Argov and Frank L. Mastaglia; 25. Myofibrillar myopathy Duygu Selcen; 26. Hereditary inclusion body myopathies Zohar Argov and Stella Mitrani-Rosenbaum; 27. Other myopathies Giovanni Meola and Michael Swash.

Editorial Reviews

5 Stars! from Doody

Reviewer: Arlene N. Barr, MD (University of Illinois at Chicago College of Medicine)
Description: This book presents the latest information on the etiology, pathogenesis, and clinical description of skeletal muscle disease. Topics include: mitochondrial myopathies, ion channel disorders, muscular dystrophies, congenital myopathies, dysimmune myopathies, toxic myopathies, and neuromuscular junction diseases. The extensive coverage of the scientific basis and methods of investigation is a welcome component. The previous edition was published in 1994.
Purpose: This book is intended to provide an up-to-date reference for the clinical and basic science aspects of the field. Without question, these are invaluable objectives because there has been a rapid expansion in information since the publication of the previous edition. The authors have provided us an outstanding book.
Audience: I agree with the authors that the book will appeal to a wide range of readers. Practicing clinicians in neurology, rheumatology, pediatrics, orthopedics, and physiatry as well as medical students, graduate students, clinical scientists, and basic scientists all should find its contents very useful. The list of contributors reads like a "Who's Who" in this field.
Features: Both clinical and basic science aspects of muscle disease are covered. There are newly described entities as well as updates on well known diseases. The most remarkable feature of this book is the comprehensive coverage of new information combined with the insights from the best thinkers that could be brought together.
Assessment: Hands down, this book is the best current publication in its category. The seventh edition is well timed to capture the massive increase of information published since the previous edition of 1994.

Doody's Review Service

'After reading through the text, one will achieve a solid foundation in clinical myology. This book will be useful for any clinician who diagnoses and manages patients with muscle disease, and for students, residents, and fellows with an interest in such.' Mark B. Bromberg, MD, PhD, Neurology

From the Publisher