Direct Oral Anticoagulants: From Pharmacology to Clinical Practice

by Riccardo Proietti (Editor), Ahmed AlTurki (Editor), Nicola Ferri (Editor), Vincenzo Russo (Editor), T. Jared Bunch (Editor)

Overview

This book concisely covers the latest developments in the application of direct oral anticoagulants (DOACs) within cardiovascular medicine. It details the pharmacodynamics and pharmacokinetic mechanisms of DOACs and their application in treating patients with conditions ranging from coronary heart disease through kidney disease and cancer, including their perioperative management.

Direct Oral Anticoagulants: From Pharmacology to Clinical Practice systematically describes the underlying mechanisms associated with DOACs and their use to treat a range of conditions and is an indispensable resource for all trainee and practicing physicians in a range of disciplines seeking a concise up-to-date resource on the topic.

Product Details

ISBN-13:	9783030744618
Publisher:	Springer International Publishing
Publication date:	06/30/2021
Edition description:	1st ed. 2021
Pages:	283
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Dr. Riccardo Proietti MD, PhD, graduated at the Catholic University of Rome in 1997. He then specialized in cardiology at the University of Perugia and achieved a PhD degree in Cardiovascular Science at the University of Padua. He accomplished a fellowship in clinical electrophysiology at McGill University Canada. Since 2010, he is Consultant Cardiologist at Luigi Sacco Hospital of Milan with main activity in cardiac pacing and electrophysiology. He is certified in cardiac pacing by the European Heart Rhythm society and in Clinical Electrophysiology by the Heart Rhythm Society. He is author of articles in national and international peer-reviewed journals and a number of book chapters.

Ahmed AlTurki completed internal medicine residency and a fellowship in cardiology at McGill University in Montreal, Canada and is currently undertaking a fellowship in cardiac electrophysiology at the same institution. His main scientific interests include oral anticoagulation for atrial fibrillation, cardiac implantable electronic devices and catheter ablation of atrial fibrillation. He has authored over peer-reviewed journal articles and several book chapters.

Nicola Ferri is Associate Professor in Pharmacology at the University of Padua. His main scientific interest is focused on drugs affecting lipid metabolism and atherosclerosis. He received several honours, among all the award “Giovani Ricercatori” by Italian Society for the study of atherosclerosis (SISA). He is elected in the organizing committee of the European Lipoprotein Club meeting (from 2017 until 2011) and of SISA Veneto section (from 2018-2022). He is authors of more than 100 peer-review manuscripts.

Vincenzo Russo undertook specialist training in Cardiology at Monaldi Hospital. He earned PhD degree in Pathophysiology of the Cardio-Respiratory System from Second University of Naples in 2013. Since 2010, Dr. Russo serves as Consultant Cardiologist at Monaldi Hospital in Naples and as Honorary Fellow in Cardiovascular Diseases at School of Medicine - University of Campania “Luigi Vanvitelli”. He has published over 100 peer-reviewed manuscripts and is an editor for Cardiology Research and Practice.

T. Jared Bunch completed internal medicine residency and fellowships in cardiovascular diseases and electrophysiology at the Mayo Clinic in Rochester Minnesota. He received the Mayo Brothers Distinguished Fellowship Award for clinical care of patients and the Donald C. Balfour Award for meritorious research. He served as an Assistant Professor of Medicine at the Mayo Clinic from 2003-2007, before joining his current partners at Intermountain Heart Rhythm Specialists. He currently directs heart rhythm research at Intermountain Medical Center and is the medical director for heart rhythm services of Intermountain Healthcare. He is involved in multiple national and international trials involving cardiac rhythm management. He has published over 100 manuscripts and 10 book chapters. He is the Editor-in-Chief of Heart Rhythm Case Reports and a section editor for Heart Rhythm.

Table of Contents

Chapter 1. The Coagulative cascade
Chapter 2 Clinical Indications for Direct Acting Oral Anticoagulants
Chapter 3. Pharmacokinetic and pharmaco-dynamic of DOAC
Chapter 4. Drug-drug interaction with DO-ACs
Chapter 5. Direct Oral Anticoagulant Reversal for Management of Bleeding and Emergent Surgery
Chapter 6. Risk stratification for and use of DOAC therapies for stroke prevention in patient with atrial fibrillation
Chapter 7. Use of DOAC in patients with kidney disease
Chapter 8. Anticoagulation In Elderly Patients With Atrial Fibrallation
Chapter 9. The “Obesity Paradox” And The Use Of NOAC
Chapter 10. Direct Oral Anticoagulation In Cancer Patients
Chapter 11. DOACs and Dementia in Patients with Atrial FibrillationChapter 12. Non-Vitamin K Antagonists and Cardiac Implantable Electronic Devices
Chapter 13. Direct Oral Anticoagulants and Atrial Fibrillation Ablation
Chapter 14. DOAC therapy in patients post left atrial appendage occlusion or isolation
Chapter 15. Use of Direct Oral Anticoagulants after Transcatheter Aortic Valve Replacement
Chapter 16. Use of Direct Oral Anticoagulants after Percutaneous Coronary Intervention
Chapter 17: Direct oral anticoagulants and Left Ventricular Thrombosis: the evidence for a good therapeutic approach

Editorial Reviews

Reviewer: Raza Hussain, Doctor of Medicine(East Tennessee State University Quillen College of Medicine)
Description: This is a multi-authored reference text on the use of direct oral anticoagulants (DOACs) in clinical practice with a focus on cardiovascular disease.
Purpose: The goal is to provide a comprehensive review of the function and role of oral anticoagulants in clinical practice. The book presents a detailed analysis of patient management with DOACs by using various clinical situations and references.
Audience: The intended audience is midlevel providers, training physicians, internists, and cardiologists. The authors are a group of diverse national and international individuals from the fields of cardiology and pharmacology.
Features: This book is divided into 17 chapters. The initial four chapters focus on the introduction of the coagulation cascade and the action of oral anticoagulants on specific pathways. It then leads to discussing clinical indications, followed by detailed pharmacology and drug-drug interactions of DOACs. The following chapter focuses on reversal agents available for DOACs and the management of patients with acute bleeding on DOACs. The remaining chapters elaborate on clinical daily practice scenarios that highlight the role of DOACs in cardiac disease and interventions. This text reviews the current guidelines and concepts set for the management of cardiac patients who require DOACs. Peer-reviewed articles provide evidence for each chapter with references provided at the end. The book utilizes clear and concise images, tables, and graphs to portray the information, making it easy for the readers to follow along. Tables regarding drug-drug interactions are especially useful for clinicians as a quick reference tool in practice.
Assessment: This book is useful for new and experienced clinicians as it provides a thorough review of DOACs in the field of cardiology. It is a great source to review current management guidelines and use as a reference when making clinical decisions in practice.

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