Diet and Cancer: Molecular Mechanisms of Interactions / Edition 1

by Maryce M. Jacobs

Overview

The fifth of the annual research conferences of the American Institute for Cancer Research was held September l-2, 1994, at the L'Enfant Plaza Hotel in Washington, DC. Appropriately, in view of current directions in research, the theme was "Diet and Cancer: Molecular Mechanisms of Interactions". This proceedings volume contains chapters from the platform presentations and abstracts from the poster session held on the end of the first day. The subtopics for the tl;rree sessions held were "Retinoids, Vitamins A and Din Cancer Prevention and Therapy," "Choline and Lipids: Signal Transduction, Gene Expression and Growth Regulation," and "Dietary Factors and Regulation of Oncogenes, Growth and Differentiation. " A general overview on vitamins A and D emphasized that A and D, in addition to their established roles in vision, reproduction, and bone mineral homeostasis, may play significant roles in regulating cell function. Vitamin A metabolites, trans-retinoic acid and 9-cis-retinoic acid, regulate growth and differentiation. Furthermore, vitamin A­ deprived animals were more susceptible to both spontaneous and carcinogen-induced tumors. Epidemiological studies showed a correlation between low A intake and higher incidences of certain types of human cancers. Conversely, all-trans retinoic acid is useful in treatment and control of certain types of cancer. Physiologically, Vitamin D is converted to the active form, l ,25-dihydroxyvitamin D (VD). VD regulates hormone production and secretion, myocardial contractility, vascu­ 3 3 3 lar tone, and growth inhibition and differentiation.

Product Details

ISBN-13:	9780306450679
Publisher:	Springer US
Publication date:	05/31/1995
Series:	Advances in Experimental Medicine and Biology , #354
Edition description:	1995
Pages:	222
Product dimensions:	7.01(w) x 10.00(h) x 0.02(d)

About the Author

Amer Inst for Cancer Research

These are the proceedings of the American Institute of Cancer Researcher's 5th Annual Conference on Diet and Cancer held in September 1994 in Washington, D.C. The contributors were participants in the conference.

Table of Contents

1 Use of Vitamins A and D In Chemoprevention and Therapy of Cancer: Control of Nuclear Receptor Expression and Function—Vitamins, Cancer and Receptors.- 2 Vitamin A Chemoprevention of Lung Cancer: A Short-Term Biomarker Study.- 3 Human Cervical Cancer: Retinoids, Interferon and Human Papillomavirus.- 4 Role of Apoptosis in the Growth Inhibitory Effects of Vitamin D in MCF-7 Cells.- 5 Vitamin D and Prostate Cancer.- 6 Choline and Hepaarcinogenesis in the Rat.- 7 Dietary Effects on Gene Expression in Mammary Tumorigenesis.- 8 Effect of Dietary Fatty Acids on Gene Expression in Breast Cells.- 9 Lipotrope Deficiency and Persistent Changes in DNA Methylation.- 10 Methionine Deprivation Regulates the Translation of Functionally Distinct c-Myc Proteins.- 11 Progressive Loss of Sensitivity to Growth Control by Retinoic Acid and Transforming Growth Factor-Beta at Late Stages of Human Papillomavirus Type 16-Initiated Transformation of Human Keratinocytes.- 12 Short-Chain Fatty Acids and Molecular and Cellular Mechanisms of Colonic Cell Differentiation and Transformation.- 13 Fish Oil and Cell Proliferation Kinetics in a Mammary Carcinoma Tumor Model.- Abstracts.

Editorial Reviews

Reviewer: Robert Treat Chatterton, PhD (Northwestern University Feinberg School of Medicine)
Description: This book represents the proceedings of the 5th annual conference of the American Institute for Cancer Research on Diet and Cancer: Molecular Mechanisms and Interactions.
Purpose: The purpose is to describe the advances in the molecular mechanisms involved in carcinogenesis, which are applied to the problems of the diet-cancer interaction. Such information is essential to progress in understanding the potential role of the diet in carcinogenesis.
Audience: The book is specifically written for the researcher in the area of diet and cancer. However, it may also be useful reading for the specialist practitioner in oncology.
Features: The book is adequately illustrated for the presentation of research data. Charts, graphs, photographs, and black-and-white histological sections are appropriate. The index and table of contents are useful, particularly because the book is a rather eclectic collection of articles.
Assessment: This is a collection of papers selected for presentation at the conference. There is no attempt to cover the topic in a systematic and balanced manner. Chapters start with vitamin A and retinoids, continue with vitamin D and its metabolites, then to choline and fatty acids, folic acid and methylation, and then back to retinoic acid and fatty acids. Mediation of dietary effects by cytokines and growth factors is described in several chapters. Vitamin C and E and minerals are not presented in any detail. Hormonal mediation of dietary effects, e.g., in breast cancer is not covered. However, the chosen topics are covered in sufficient depth for the researcher. Although it is convenient to have a collection of related papers under one cover, the advantages over reading the papers in peer reviewed journals may not justify the book in the minds of many investigators.

Doody's Review Service

Reviewer: Robert Treat Chatterton, PhD(Northwestern University Feinberg School of Medicine)
Description: This book represents the proceedings of the 5th annual conference of the American Institute for Cancer Research on Diet and Cancer: Molecular Mechanisms and Interactions.
Purpose: The purpose is to describe the advances in the molecular mechanisms involved in carcinogenesis, which are applied to the problems of the diet-cancer interaction. Such information is essential to progress in understanding the potential role of the diet in carcinogenesis.
Audience: The book is specifically written for the researcher in the area of diet and cancer. However, it may also be useful reading for the specialist practitioner in oncology.
Features: The book is adequately illustrated for the presentation of research data. Charts, graphs, photographs, and black-and-white histological sections are appropriate. The index and table of contents are useful, particularly because the book is a rather eclectic collection of articles.
Assessment: This is a collection of papers selected for presentation at the conference. There is no attempt to cover the topic in a systematic and balanced manner. Chapters start with vitamin A and retinoids, continue with vitamin D and its metabolites, then to choline and fatty acids, folic acid and methylation, and then back to retinoic acid and fatty acids. Mediation of dietary effects by cytokines and growth factors is described in several chapters. Vitamin C and E and minerals are not presented in any detail. Hormonal mediation of dietary effects, e.g., in breast cancer is not covered. However, the chosen topics are covered in sufficient depth for the researcher. Although it is convenient to have a collection of related papers under one cover, the advantages over reading the papers in peer reviewed journals may not justify the book in the minds of many investigators.

This book represents the proceedings of the 5th annual conference of the American Institute for Cancer Research on Diet and Cancer: Molecular Mechanisms and Interactions. The purpose is to describe the advances in the molecular mechanisms involved in carcinogenesis, which are applied to the problems of the diet-cancer interaction. Such information is essential to progress in understanding the potential role of the diet in carcinogenesis. The book is specifically written for the researcher in the area of diet and cancer. However, it may also be useful reading for the specialist practitioner in oncology. The book is adequately illustrated for the presentation of research data. Charts, graphs, photographs, and black-and-white histological sections are appropriate. The index and table of contents are useful, particularly because the book is a rather eclectic collection of articles. This is a collection of papers selected for presentation at the conference. There is no attempt to cover the topic in a systematic and balanced manner. Chapters start with vitamin A and retinoids, continue with vitamin D and its metabolites, then to choline and fatty acids, folic acid and methylation, and then back to retinoic acid and fatty acids. Mediation of dietary effects by cytokines and growth factors is described in several chapters. Vitamin C and E and minerals are not presented in any detail. Hormonal mediation of dietary effects, e.g., in breast cancer is not covered. However, the chosen topics are covered in sufficient depth for the researcher. Although it is convenient to have a collection of related papers under one cover, the advantages over reading the papers in peer reviewed journals may notjustify the book in the minds of many investigators.

Robert T. Chatterton

Comprises the proceedings from the fifth annual research conference of the American Institute for Cancer Research held in September 1994 in Washington, DC. Topics covered include retinoids and vitamins A and D in cancer prevention and therapy; choline and lipids--signal transduction, gene expression, and growth regulation; and dietary factors and regulation of oncogenes, growth, and differentiation. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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