Diabetic Nephropathy: Pathophysiology and Clinical Aspects

by Joris J. Roelofs, Liffert Vogt

Overview

This book provides an overview of the most up-to-date research on diabetic nephropathy and the current understanding of its pathogenesis, clinical features and socio-economic developments. Written by leading experts in the field, it provides a comprehensive synthesis of clinical and pathophysiological aspects from a mechanism-based point of view, and reviews evidence-based treatment modalities for the prevention and management of diabetic nephropathy. In addition, closely related areas such as diabesity, diabetic eye disease and macrovascular involvement in diabetes are addressed.

Diabetic Nephropathy will be of interest for nephrologists, diabetologists, internists, transplant physicians, public health professionals, basic scientists, geneticists, epidemiologists, pathologists, and molecular and cell biologists working in the field of diabetes and its complications.

Product Details

ISBN-13:	9783319935201
Publisher:	Springer International Publishing
Publication date:	10/30/2018
Edition description:	1st ed. 2019
Pages:	548
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Joris J. Roelofs, MD, PhD

Joris Roelofs (1972) studied medicine at the KU Leuven, Belgium, and the VUmc School of Medical Sciences, Amsterdam, the Netherlands, where he received his MD degree. He received his PhD degree from the University of Amsterdam Faculty of Medicine with studies on coagulation in renal disease, after which he worked as a Postdoctoral Research Fellow in the Kirkland Center for Lupus Research (Cornell University Medical College, New York City). Joris Roelofs is Associate Professor of Renal Pathology and Principal Investigator in the Department of Pathology at the Academic Medical Center, Amsterdam, where he leads translational studies in chronic kidney disease and diabetic nephropathy.

Liffert Vogt, MD, PhD

Liffert Vogt (1975) was born in Groningen in the Netherlands, where he completed his medical degree and nephrology PhD. He then moved to the Mario Negri Institute, Bergamo, Italy where he was an international postdoctoral fellow, and then he completed his internal medicine and nephrology training at the Academic Medical Center, Amsterdam, the Netherlands, where he works now as an internist and nephrologist. As a Principal Investigator in his institute, he is leading experimental and clinical studies within the field of diabetes and chronic kidney disease.

Table of Contents

1. Diabetic nephropathy – Scope of the problem.- Historical overview of diabetic kidney disease.- Clinical features and natural course of diabetic nephropathy.- Global, regional and ethnic differences in diabetic nephropathy.- Diabetic nephropathy in children and adolescents.- Renal disease in obesity, metabolic syndrome and diabesity.- 2. Pathophysiology and clinical pathology of the diabetic kidney.- Introduction to pathogenetic mechanisms of diabetic nephropathy.- The genetics of diabetic nephropathy.- Pathology of the kidney in diabetes.- 3. The glomerulus.- The mesangial cell in diabetic nephropathy.- The glomerular endothelium in diabetic nephropathy - role of heparanase.- The podocyte in diabetic nephropathy: recent advances.- Inflammatory processes in diabetic glomeruli.- 4. The tubulointerstitium.- Proteinuria and tubulotoxicity.- Tubulo-glomerular communication in diabetic nephropathy.- Mechanisms of interstitial fibrosis in diabetic nephropathy.- 5. Microvascular involvement.- Microvascular damage and hemodynamic alterations in diabetic nephropathy.- Coagulation and hemostasis in diabetic nephropathy.- Renal hemodynamics in diabetic kidney disease - relevance for intervention.- Microvascular complications in the eye: diabetic retinopathy.- 6. Macrovascular involvement.- Hypertension in diabetic kidney disease.- Macrovascular involvement in diabetes - renal artery stenosis.- Atherosclerosis and diabetic nephropathy.- 7. Experimental designs.- Animal models of diabetic kidney disease.- Clinical trial and error in diabetic nephropathy.- 8. Therapy of diabetic nephropathy.- Treatment goals in diabetic nephropathy.- Kidney transplantation and diabetic nephropathy.- 9. Future developments.- Health programs in low- and middle-income countries.- OMICs in diabetic kidney disease.- Future and novel compounds in the treatment of diabetic nephropathy.

Editorial Reviews

Reviewer: Amita Maibam, MD, MPH (University of Kentucky College of Medicine)
Description: Diabetes is a vast and complicated disease, which is further compounded by the fact that it has become one of the biggest enemies of healthcare on a truly global scale. It's easy to underestimate its impacts, but no one can ignore the truth that we need to understand this disease holistically if we want to conquer it. This is a comprehensive overview of diabetic kidney disease, including future directions.
Purpose: The aim is to present an exhaustive description of diabetic nephropathy. The book describes the different facets of this complicated disease from broad epidemiological aspects to the granularity of molecular mechanisms. The main goal is to provide a solid understanding of this subject in order to translate complex knowledge into better patient care.
Audience: This book will be suitable for basic researchers, practicing nephrologists/diabetologists/internists, fellows, residents, medical students, and public health workers.
Features: The book's nine parts sequentially go through different aspects of the disease. The book starts the journey by presenting the problem, then describes the pathophysiology and pathogenesis before delving into the description of different anatomic compartments of the kidney pertaining to diabetes. It then describes the macrovascular involvement and discusses the experimental designs before talking about management. It wraps up the journey by focusing on future directions. This process has been simplified by dividing the material into 29 chapters, each of which provides a thorough explanation of relevant concepts. The book may sound exhaustive, but it's very easy to locate an area of interest. The information is precise, and the knowledge can be assimilated without much difficulty. Graphs, tables, and pictures help clarify difficult ideas whenever necessary.
Assessment: This is an excellent reference that fosters an understanding of the minute details of this disease and its far-reaching repercussions. Trainees can get in-depth information, practicing physicians can get a quick answer to a pressing question, and researchers can find food for thought in creating new questions. The organized and well-written book has several learning pearls throughout. Contributions by renowned experts raise the quality level to meet the needs of all who seek guidance in this area. Dedicated topics on experimental designs and future developments emphasize the need for continued work towards improving the care of patients with diabetic nephropathy. Some of the text is dense and may challenge readers' attention at times. Hopefully this can be improved in subsequent editions. Overall, this is an excellent source of answers to a great many questions that arise while dealing with diabetes and its numerous effects. It fills a big gap and comes to the rescue at a time of need.

Doody's Review Service

This book will be suitable for basic researchers, practicing nephrologists/diabetologists/internists, fellows, residents, medical students, and public health workers. … this is an excellent source of answers to a great many questions that arise while dealing with diabetes and its numerous effects. It fills a big gap and comes to the rescue at a time of need.” (Amita Maibam, Doody's Book Reviews, May 31, 2019)

From the Publisher