Diabetes: Oxidative Stress and Dietary Antioxidants

by Victor R Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC

Overview

Diabetes: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide among diabetologists, endocrinologists, and nutritionists in understanding and treating diabetes. The book covers, in a single volume, the science of oxidative stress in diabetes and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, receptor-mediated responses and more. This approach recognizes that diseases are usually multifactorial and that oxidative stress is a single component of this.Pharmacological treatments for diabetes are commonly marked by unwanted side effects, leading to treatment efforts using naturally occurring substances. But a plant-based approach alone is not sufficient; understanding the processes inherent in the oxidative stress of diabetes is vital for clinical workers, dietitians, and nutritionists.This translational work provides that understanding. The book begins by covering the basic biology of oxidative stress from molecular biology to imaging in relation to diabetes. There are chapters on neuropathy, nephropathy, atherosclerosis, cardiomyopathy, and retinopathy. The book then moves on to antioxidants in foods, including plants, components of the diet, and their relevance to diabetes.

Product Details

ISBN-13:	9780124058859
Publisher:	Elsevier Science
Publication date:	11/14/2013
Pages:	280
Product dimensions:	11.10(w) x 14.00(h) x 1.10(d)

About the Author

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.

Table of Contents

1. Oxidative stress and diabetic neuropathy 2. Oxidative stress in diabetic nephropathy
3. Oxidative stress in diabetic atherosclerosis
4. Diabetic stroke and oxidative stress
5. Diabetic cardiomyopathy and oxidative stress
6. Oxidative stress in diabetic retinopathy
7. Beta glucan and neuroprotection in diabetes
8. Selenium and diabetic peripheral neuropathy
9. Neuropathy and micronutrients supplementation
10. Nigella sativa oil, diabetic neuropathy and oxidative stress
11. Diabetic nephropathy, propolis and oxidative stress
12. Green tea, oxidative stress and diabetic nephropathy
13. Diabetic nephropathy and tocotrienol
14. Resveratrol, diabetic nephropathy and oxidative stress
15. Anti-RAGE compounds, atherosclerosis and diabetes
16. Vitamin E and vascular protection in diabetes
17. Ginkgo biloba, atherosclerosis protection in diabetes
18. Zinc supplementation and oxidative stress of vascular tissues
19. Taurine and cardiac oxidative stress
20. Statins, diabetic oxidative stress and vascular tissue
21. Herbal Chrysanthemi Flos, oxidative damage and diabetic vascular protection
22. Antioxidant supplements and diabetic retinopathy
23. Neuroprotective lutein in the retina
24. Anti-oxidant related micronutrients and diabetic retinopathy
25. Resveratrol, oxidative stress and diabetic liver
26. Pomegranate juice, oxidative stress and the lung in diabetes
27. Rosemary extract in diabetes
28. Antioxidative effects of allium cepa in diabetes
29. Citrus flavonoids and oxidative stress in diabetes
30. Oxidative stress, diabetes and iron
31. Gingseng, diabetes and oxidative stress

What People are Saying About This

From the Publisher

Translational coverage on how dietary antioxidants and oxidative stress contribute to, and protect from, diabetes and diabetic complications

Editorial Reviews

Reviewer: Colleen Majewski, MD (University of Chicago Medical Center)
Description: This book describes the various complications of diabetes mellitus, focusing on the role of oxidative stress in these patients. It details how hyperglycemia contributes to the common complications and details the data on treatment with antioxidants to counter them.
Purpose: The purpose is to describe how oxidative stress is important in the pathophysiology of diabetic complications, and the book also reviews the available data on treatment options with antioxidants. These are important objectives given the prevalence of diabetic complications and minimal treatment other than maintaining euglycemia.
Audience: The book is written for both practitioners and scientists studying this topic. It describes the physiology at the cell level leading to oxidative damage in the hyperglycemic patient. It is a useful reference for practitioners wanting to expand their available treatment options for their diabetic patients who have complications.
Features: It reviews the pathophysiology of how oxidative stress contributes to diabetic complications such as neuropathy, cerebral ischemia, cardiomyopathy, nephropathy, and retinopathy and describes the studies that have investigated the various antioxidant treatments available and their effect on diabetic complications. This is a novel way to think about diabetic complications and an important topic to review.
Assessment: This is a comprehensive review of the mechanisms leading to diabetic complications with a specific focus on oxidative stress as well as an important review of antioxidant therapies that have been studied in the diabetic population.

Doody's Review Service

"Each volume in the Oxidative Stress and Dietary Antioxidants series focuses on the phenomena in a single organ, disease, or pathology. Diabetes takes the spotlight here, with discussions of such matters as mitochondrial oxidative stress in diabetes, antioxidant spices and herbs used in diabetes…The material is for dietitians and nutritionists, food scientists, health care workers, and researchers." —ProtoView.com, February 2014

"The book is written for both practitioners and scientists studying this topic… It is a useful reference for practitioners wanting to expand their available treatment options…This is a comprehensive review of the mechanisms leading to diabetic complications with a specific focus on oxidative stress as well as an important review of antioxidant therapies that have been studied in the diabetic population." Rating: 3 Stars —Doody.com, February 21, 2014

From the Publisher