In this new edition of the acclaimed Dementia: Presentations, Differential Diagnosis, and Nosology, V. Olga B. Emery, Ph.D., and Thomas E. Oxman, M.D., bring together a distinguished group of medical authorities—including many who have done seminal research in this field—to discuss the spectrum of dementing disorders and explain their overlap, presentations, and differential diagnosis. The chapters present original data as well as material from the authors' clinical experiences. Current classification systems are evaluated and modified to better account for common presentations of dementia.
Thoroughly revised, updated, and expanded, the second edition includes new material on neuroimaging, genetics, the role of inflammation in Alzheimer disease, retrophylogenesis in Alzheimer memory, and on AIDS dementia. In addition, each chapter includes a new section entitled describing clinical applications.
V. Olga B. Emery, Ph.D., is an adjunct associate professor of psychiatry at Dartmouth Medical School and director of the New Hampshire Center on Aging, Health and Society. She also holds an appointment at Harvard Medical School.
Thomas E. Oxman, M.D., is a professor of psychiatry and community and family medicine at Dartmouth Medical School.
Table of Contents
List of ContributorsAcknowledgmentsList of AbbreviationsIntroductionPART I: Background, Concepts, and Diagnostics1. Boundaries between Normal Aging and Dementia: Perspectives from Neuropsychological and Neuroimaging Investigations2. The Spectrum of Dementias: Construct and Nosologic Validity3. Diagnostic Procedures for DementiaPART II: Alzheimer Dementias4. The Neuropathology of Alzheimer Dementia5. Neural Inflammatory Mechanisms in Alzheimer Syndrome6. Clinical Subgroups of Alzheimer Disease7. Progressive Aphasia, Frontotemporal Dementia and Other "Focal Dementias"8. "Retrophylogenesis" of Memory in Dementia of the Alzheimer Type: A New Evolutionary Memory FrameworkPART III: Vascular Dementias and Subcortical Dementias9. Cortical and Frontosubcortical Dementias: Differential Diagnosis10. Noninfarct Vascular Dementia: The Spectrum of Vascular Dementia and Alzheimer Syndrome11. The Relationship of Hypertension to Vascular Dementia12. Vascular Dementias and Alzheimer Disease: Differential Diagnosis13. Acquired Immunodeficiency Syndrome Dementia ComplexPART VI: Depressive Dementias14. Depressive Dementia: A "Prepermanent Intermediate-stage Dementia" in a Long-term Disease Course of Permanent Dementia?15. Depressive Dementia: Cognitive and Biological Correlated and Course of Illness16. The Nondepressive Pseudodementias17. Neurobiology of Major Depression in Alzheimer Disease18. Approaches to the Treatment of Dementing Illness19. The Spectra of the DementiasIndex
This book takes the pragmatic, clinical, long-term care issues through the interesting, yet difficult scientific, etiologic, clinical, differential diagnosis, theoretical and nosological aspects of dementia, all in one edited volume. Alzheimer dementias, vascular dementias, depressive dementias, and nondepressive "pseudodementias" are covered in depth.
