Cytomegalovirus: Biology and Infection / Edition 1

by Monto Ho

Overview

Although there are a number of excellent current reviews on one or another aspect of cytomegalovirus, the last comprehensive treatment of this subject was that of Krech et al. (1971a). In view of the amazing advances in the virological, epidemiologic, and clinical knowledge of cytomegaloviruses, an up-to-date book is needed. Such a work should cover many areas of expertise and a voluminous technical literature. Each area might have been reviewed and analyzed by workers more expert than myself. However, I have embarked on the entire venture alone in order to attain unity and continuity in this book, characteristics that are not easily achieved in the more popular multiauthored works. I have tried to review the literature and to provide a critical summary for each area discussed. To do this, I provide as much of the primary data of the relevant works as needed and not just the qualitative conclusions. Inevitably, the flow of the narrative may be interrupted by dry facts and figures. However, such information is essential to make this a meaningful reference work. But for those not interested in such details, I have provided at what I hope are crucial points critiques and summaries. This book is not an exhaustive review of all the literature. This is probably no longer possible or even desirable. By selection, however, one runs the risk of having missed or ignored important papers. I am keenly aware of this, and I wish to apologize for such oversight, if that is possible.

Product Details

ISBN-13:	9781468440751
Publisher:	Springer US
Publication date:	12/12/2012
Series:	Current Topics in Infectious Disease
Edition description:	Softcover reprint of the original 1st ed. 1982
Pages:	310
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

1. History of Cytomegalovirus.- 2. Molecular Biology of Cytomegalovirus Replication.- 3. Gene Products of Cytomegalovirus and Their Immunologic Significance.- 4. Characteristics of Cytomegalovirus.- 5. Virological Diagnosis and Infections in Cells and Tissues.- 6. Serologic Tests for Cytomegalovirus Infections.- 7. Cell-Mediated Immunity to Cytomegalovirus Infection.- 8. Variants of Human Cytomegalovirus.- 9. Epidemiology of Cytomegalovirus Infection in Man.- 10. Pathology of Cytomegalovirus Infection.- 11. Congenital and Perinatal Human Cytomegalovirus Infections.- 12. Acquired Cytomegalovirus Infection in Immunocompetent Patients.- 13. Human Cytomegalovirus Infections in Immunosuppressed Patients.- 14. Treatment and Prevention of Cytomegalovirus Infections.- 15. Nonhuman Cytomegaloviruses.- 16. Murine Cytomegalovirus.- References.- Author Index.

Editorial Reviews

In order to account for the recent manifold success of cytomegaloviruses--primarily as opportunistic infections associated with AIDS--and the resulting research, the new edition of the literature review has been almost entirely rewritten, maintaining little more than the structure of the 1982 first edition. The emphasis is on newer insights in virology, immunology, serology, epidemiology, and clinical aspects, presenting much of the original data as well as the various authors' conclusions. New chapters cover molecular biology and gene products. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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