Cytokeratins in Intracranial and Intraspinal Tissues

by Michael Bauer

Overview

This book summarises current immunomorphological data of cytokeratin detection in the various cell types of intracranial and intraspinal tissues.The methodical problems of their detection are discussed as well as the interspecies variability in the expression of intermediate filaments. Together with the microtubuli and the microfilaments, intermediate filament proteins represent the main constituents of the vertebrate cell cytoskeleton. The review specifically focuses on the most up-to-date material concerning cytokeratin expression inselected neutoectodermal tissues, for which only sparse results exist. Essential information on the latest findings in this field coupled with new experimental data by the author are provided in this volume.
Chapters review methodical aspects and problems in the evaluation of filament proteins by immunocyhemistry and explore the relationship of cytokeratin expression to cellular differentiation. Also discussed are: function of intermediate filaments; species differences in the expression during ontogeny; and pathologic alteration of tissues and tumor development.

Product Details

ISBN-13:	9783540551614
Publisher:	Springer Berlin Heidelberg
Publication date:	08/26/1992
Series:	Advances in Anatomy, Embryology and Cell Biology , #126
Pages:	82
Product dimensions:	6.69(w) x 9.53(h) x (d)

Table of Contents

1 Introduction.- 1.1 The Cytokeratins as a Member of the Intermediate Filament Protein Family.- 1.2 Coexpression of Intermediate Filaments.- 1.3 The Aim of This Study.- 2 Methodological Aspects.- 3 Fetal Development of Neuroectodermal Structures.- 4 Choroid Plexus and Ependyma.- 5 The Subcommissural Organ.- 6 Ciliary and Retinal Pigment Epithelia of the Eye.- 7 Heterogeneity in the Immunolocalization of Cytokeratin-Specific Monoclonal Antibodies in Neuroectodermal Structures.- 8 The Arachnoidea.- 9 Pituitary Gland Epithelia and Adenomas.- 9.1 Endocrine Cells and Pituitary Adenomas.- 9.2 Folliculostellate Cells and Rathke’s Cysts.- 10 Cytokeratin in Glial Cells and in Tumors of Glial Origin.- 11 Cytokeratins in Nerve Cells.- 12 Neural Crest Derivatives.- 13 Cytokeratin Expression in Tumors of Neuroectodermal Origin.- 14 Implications on Cell Function and Differentation.- 15 Conclusions.- 16 Summary.- Refference.- Note Added in proof.