Control of Messenger RNA Stability

by Joel G. Belasco (Editor), George Brawerman (Editor)

Overview

This is the first comprehensive review of mRNA stability and its implications for regulation of gene expression. Written by experts in the field, Control of Messenger RNA Stability serves both as a reference for specialists in regulation of mRNA stability and as a general introduction for a broader community of scientists.

• Provides perspectives from both prokaryotic and eukaryotic systems
• Offers a timely, comprehensive review of mRNA degradation, its regulation, and its significance in the control of gene expression
• Discusses the mechanisms, RNA structural determinants, and cellular factors that control mRNA degradation
• Evaluates experimental procedures for studying mRNA degradation

Product Details

ISBN-13:	9780080916521
Publisher:	Elsevier Science
Publication date:	12/02/2012
Sold by:	Barnes & Noble
Format:	eBook
Pages:	517
File size:	7 MB

Table of Contents

Prokaryotes. Mrna Degradation in Prokaryotic Cells: An Overview. The Role of the 3' End in Mrna Stability and Decay. 5'mrna Stabilizers. RNA Processing and Degradation By Rnase E and Rnase K. RNA Processing and Degradation By Rnase III. Translation and Mrna Stability in Bacteria: A Complex Relationship. Eukaryotes. Mrna Degradation in Eukaryotic Cells: An Overview. Hormonal and Developmental Regulation of Mrna Turnover. Control of the Decay of Labile Proto-Oncogene and Cytokine Mrnas. Translationally Coupled Degradation of Tubulin Mrna . Iron Regulation of Tranferrin Receptor Mrna Stability. Degradation of a Non-Polyadenylated Messenge: Histone Mrna Decay. Mrna Turnover in Saccharomyces Cerevisiae. Control of Mrna Degradation in Organelles. Control of Poly(A) Length. Mrna Decay in Cell-Free Systems. Eukaryotic Nucleases and Mrna Turnover. Experimental Approaches to the Study of Mrna Decay

Editorial Reviews

A comprehensive review of mRNA stability and its implications for regulation of gene expression, serving both as a reference for specialists in the field of mRNA degradation and as a general introduction for the broader community of biological scientists. The volume is divided into three parts. Parts I and II deal with various aspects of mRNA degradation in prokaryotic and eukaryotic cells. Part III provides a critical examination of experimental procedures for studying mRNA decay and is intended primarily as a guide for newcomers to the field. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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