Comprehensive Bioactive Natural Products (Extraction, Isolation & Characterization)

by V.K. GUPTA, S.C. TANEJA

Overview

Natural products have always been and will remain important sources of new drug molecules. Resurgence in the use of Herbal drugs and the need for their standardization on the basis of Marker compounds gave a boost to research on natural products during the last two decades. Advances in isolation and structure determination methods including hyphenated techniques like GC-MS, LC-PDA, LC-MS, LC-FTIR, LC-NMR, LC-NMR-MS, CE-MS and X-Ray analysis coupled with online identification have proved a boon to research in natural products. A sound isolation strategy has helped in the isolation and characterization of many bioactive molecules. Bioactivity guided extraction and fractionation of medicinal plants is a feature of routine in isolating bioactive components from natural sources. These techniques are not only restricted to plant sources but are being applied to microbial, marine and even fungal sources. The present volume Extraction, Isolation & Characterization in the series Comprehensive Bioactive Natural Products incorporates research articles and review papers written by experts in the field of natural product chemistry covering the latest trends in research on biomolecules including isolation methods and structure determination.

Product Details

ISBN-13:	9781626993471
Publisher:	Arts & Science Academic Publishing
Publication date:	06/30/2010
Sold by:	Barnes & Noble
Format:	eBook
Pages:	437
File size:	13 MB
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About the Author

Dr. Vijay Kumar Gupta, Ph.D., FLS, London (born 1953-) Deputy Director & Head, Animal House, Indian Institute of Integrative Medicine (CSIR), Jammu, India. He did his M.Sc. (1975) and Ph.D. (1979) in Zoology both from University of Jammu, Jammu-India. His research capabilities are substantiated by his excellent work on histopathology, ecology and reproductive biology of fishes, turtles, birds and mammals, which has already got recognition in India and abroad. Dr. Gupta has to his credit more than 75 scientific publications and review articles which have appeared in internationally recognized Indian and foreign journals. Founder fellow, life member and office bearer of many national societies, academies and associations. He has successfully completed a number of research/consultancy projects funded by various governments, private and multinational agencies. His current areas of interest are histopathology, toxicology, pre-clinical safety pharmacology and reproductive efficacy studies of laboratory animals. He is also Editor-in-chief of the books 1) Utilisation and Management of Medicinal Plants 2) Medicinal Plants: Phytochemistry, Pharmacology and Therapeutics 3) Perspectives in Animal Ecology and Reproduction (Vols.1-6). The Editor-in-chief of the American Biographical Institute, USA, has appointed him as Consulting Editor of The Contemporary Who’s Who. Dr. Gupta also appointed as Nominee for the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA, Govt. of India). Recently the Linnaean Society of London, U.K. has awarded fellowship to him in November 2009 in recognition of his contribution towards the cultivation of knowledge in Science of Natural History.



Dr. Subhash Chandra Taneja (born 1950-) obtained his masters degree in Organic Chemistry in 1971 and thereafter completed Ph.D. in Birla Institute of Technology & Science, Pilani, India in 1975 under the guidance of Prof.H.P. Tiwari. He is scientist of eminence and presently working as Scientist ‘G’, Indian Institute of Integrative Medicine (CSIR), Jammu. Dr. Taneja has over 100 publications in international journals, two book chapters and two review articles, 38 patents of which 14 are USP. He has also visited Institute of Organic Chemistry, Warsaw, Poland (1989-1990) under CSIR Scientist Exchange Programme. His areas of interest are chemistry and bioactivities of medicinal plants and generation of semi-synthetic libraries based on natural product scaffolds; design and synthesis of bioactive lead molecules in the area of inflammation, oncology, infectious diseases, immunomodulation; exploitation of microbial biodiversity for the identification newer sources of biocatalysts e.g. lipases, esterases, glucosidases, nitrilases, oxido-reductases etc. and development of new throughput screening techniques; synthesis and kinetic resolution of important dugs/intermediates using chemo-enzymatic methods; development of green methodologies for the synthesis of mono terpenes and perfumery molecules; development of new glycosylation methodologies; C- and O-glycosylation techniques; new synthetic protection-deprotection methodologies for carbohydrates, and their conversion to bioactive molecules and organic synthesis of natural products and bioactive molecules.