Clinical Pharmacology for Anesthesiology / Edition 1

by Ken B. Johnson

Overview

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Clinical Pharmacology for Anesthesiology incorporates the latest research and effectively details what anesthesia care providers must know about the drugs they use in everyday practice.

This comprehensive textbook uses a visual approach with an abundance of tables and illustrations to assist the practicing anesthesia care provider, resident, and student of anesthesia. The text begins with an overview of fundamental pharmacology concepts (pharmacokinetics, pharmacodynamics, and drug interactions) and then details all classes of drugs relevant to the anesthesiologist in a highly clinical manner.

Features

• Applies clinical pharmacology principles to patient care, focusing on how anesthetic drugs interact with one another in regards to analgesia, sedation, and hypnosis.
• Delivers a concise overview of anesthetics and other drugs (diuretics, antiemetics, antiseizure medications, etc.) used in the perioperative environment
• Describes how patient covariates, such as body weight, blood loss, and age influence drug behavior
• Incorporates the use of computer simulations to visually present drug concentration and effects forselected anesthetic techniques in premedication, induction, maintenance, emergence, and sedation
• Includes simulations of sample anesthetic techniques for various challenging surgical procedures

Product Details

ISBN-13:	9780071736169
Publisher:	McGraw Hill LLC
Publication date:	11/12/2014
Pages:	512
Product dimensions:	7.40(w) x 9.20(h) x 0.90(d)

About the Author

Ken B. Johnson, MD (Salt Lake City, UT) is Associate Professor,Learned Family Associate Professorship; Director, Center for Patient Simulation,Department of Anesthesiology, The University of Utah School of Medicine.

Table of Contents

Section I: A basic primer (i.e. easy to ready with lots of figures)1. Pharmacokinetics2. Pharmacodynamics3. Biophase4. Drug interactions5. Covariates of interest (age, weight, comorbidities, etc).Section II: For each drug, clincal features of: Pharmacokinetics(some interesting facts like % protien binding, volume ofdistribution, but more importantly, how age, weight, andcomorbidities impact drug concentrations, how drugs behavewhen given as a bolus or as a continuous infusion);Pharmacodynamics; Simulations of onset and duration of effectfor commonly used doses; Common toxicity issues and adversefeatures (focus only on those that anesthesia clinicians worryabout); Unique characteristics (i.e. context sensitive half time);Common preparations (especially for drugs that have to bedissolved) and dosing regimens (bolus versus continuousinfusion)6. Analgesics7. Sedatives8. Inhalation Agents9. Muscle Relaxants10. Reversal Agents11. Vasoactive Drugs (inotopres, chronotropes, cholinergic andanticholinergic drugs)Section III: Drug interactions for commonly used anesthetic drugcombinations: a look at analgesia for moderate and severestimuli, sedation, loss of responsiveness, and muscle relaxation.Section IV: Suggested dosing strategies for unique or challenginganesthetics. This section would be simulation based and use PKand combined drug PD interaction models.12. Drug models13. Preoperative sedation14. Moderate sedation for MAC cases15. Approaches to general anesthesia (conventional TIVA, andmultimodal)16. Post operative pain (both PACU and inpatient management)Section V: Cases17. Moderate sedation cases with more than minimal painfulstimuli in the elderly (i.e.An approach to analgesia for aretrobulbar block).18. A quick wake up after general anesthesia yet provideanalgesia for moderate to severe surgical pain19. An approach to opioid tolerant patients for surgeriesassociated with moderate to severe surgical pain20. An approach to pateints that have lost a considerable amountof blood21. A clinician's guide to dosing PCA's especially in opioidtolerant patients22. Dosing considerations for obese patients with sleep apnea23. General anesthsia for patients with poor cardiac function24. General anesthesia for patient with poor liver function25.CABG or valve replacement,26.Liver transplant27. AAA repair28. Aneurysm clipping29. Aortic arch procedures that require cirulatory arrest.