Cholesterol, Lipoproteins, and Cardiovascular Health: Separating the Good (HDL), the Bad (LDL), and the Remnant

by Anatol Kontush

Overview

Discover the biology, biochemistry, and medical aspects of lipoproteins in this comprehensive overview of its historic and contemporary development

The fatty substance known as cholesterol is found in every cell of the human body and carries out several important functions. It is transported through the bloodstream as a part of particles called lipoproteins, which are divided into classes including low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Distinguishing between these two classes, along with the ‘remnant cholesterol’ particles that have recently been associated with heightened risk of heart disease and stroke, is a crucial part of managing health and developing novel pharmaceuticals.

Cholesterol, Lipoproteins, and Cardiovascular Health offers a thorough and rigorous overview of these particles, their properties, and their methods of categorization. Surveying both the characteristics of lipoproteins and their interactions with diet, lifestyle, therapeutics, and general health, it’s an indispensable guide to these particles that can literally mean the difference between life and death. Cutting-edge and grounded in the latest research, it’s a one-stop shop for understanding blood plasma lipoproteins in all their major forms.

Cholesterol, Lipoproteins, and Cardiovascular Health readers will also find:

• Detailed discussion of topics including basic lipoprotein biochemistry, targeted therapeutics and drug development, and many more
• Easily readable overview of the current state of research into lipoproteins and their likely future applications
• Rich illustrative material enhanced by a graphical abstract at the beginning of each section offering a summary of crucial content

Cholesterol, Lipoproteins, and Cardiovascular Health is suited for professionals, clinicians, and readers looking for a comprehensive overview of all aspects of plasma lipoproteins and their role in heart disease and stroke.

Product Details

ISBN-13:	9781394158379
Publisher:	Wiley
Publication date:	10/22/2024
Pages:	384
Product dimensions:	7.20(w) x 10.10(h) x 1.00(d)

About the Author

Anatol Kontush, PhD, is Research Director at Sorbonne University, and the lead author of High-Density Lipoproteins: Structure, Metabolism, Function and Therapeutics(Wiley, 2012).

Table of Contents

Brief History of Lipoproteins xi

Preface xiii

Acknowledgments xvii

Abbreviations xix

Prologue xxi

Setting: Realms of Molecules, Cells and Diseases 1

1 Covert World of Molecules 3

2 Enigmatic World of Cells and Organs 15

3 Shadowy World of Diseases 21

Characters: Lipoproteins of Human Blood 55

Main Character One: LDL, Carrier of "Bad" Cholesterol 69

4 LDL - Why It Is Important 71

5 LDL-What It Is 93

6 LDL - Where It Comes From 105

7 LDL-What It Does 109

8 LDL - How It Stops Working 115

9 LDL - What to Do to Correct It 131

Main Character Two: HDL, Carrier of "Good" Cholesterol 155

10 HDL - Why It Is Important 157

11 HDL - What It Is 171

12 HDL - Where It Comes From 195

13 HDL - What It Does 209

14 HDL - How It Stops Working 221

15 HDL - What To Do To Correct It 233

Main Character Three: Triglyceride-Rich Lipoproteins, Carriers of Remnant Cholesterol 259

16 Remnant Cholesterol - Why It Is Important 261

17 Remnant Cholesterol - What It Is 269

18 Remnant Cholesterol - Where It Comes From 283

19 Remnant Cholesterol - What It Does 289

20 Remnant Cholesterol - How It Stops Working 295

21 Remnant Cholesterol - What to Do to Correct It 305

Test Your Knowledge 318

Answers 320

Further Reading 321

Epilogue 325

Glossary 327

Index 333