Chemoattractant Ligands and Their Receptors

by Richard Horuk

Overview

Chemoattractant Ligands and Their Receptors succinctly summarizes cutting-edge research in the important area of chemoattraction in immunology. It explains how chemoattractant molecules mobilize immune cells to ward off attack by invading pathogens, both at a molecular and at a cellular level. Written by acknowledged experts in the field, it contains detailed molecular and structural information on each of the major chemoattractants and their receptors. Its unique multidisciplinary approach encompasses biology, immunology, protein chemistry, and molecular biology. A time-saving reference for both researchers and students.

Product Details

ISBN-13:	9781000722697
Publisher:	CRC Press
Publication date:	01/31/2020
Sold by:	Barnes & Noble
Format:	eBook
Pages:	400
File size:	17 MB
Note:	This product may take a few minutes to download.

About the Author

Richard Horuk, Ph.D., is a Senior Scientist in the Department of Immunology at Berlex BioSciences, Richmond, California. Dr. Horuk received his B.Sc. Degree in Applied Biology from Trent Polytechnic, Nottingham, U.K., in 1977 and his Ph.D. Degree in Biochemistry in 1980 from Birkbeck College, University of London, U.K. He was a Postdoctoral fellow from 1981 to 1983 working in the laboratory of Dr. Martin Rodbell at the National Institutes of Health, Bethesda, Maryland. In 1983 he joined Dr. Jerrold Olefsky's laboratory at the University of California San Diego to pursue further studies on insulin action, after which he was appointed as an assistant researcher. In 1986 Dr. Horuk was appointed Principal Scientist at the Dupont Company in Glenolden, Pennsylvania, where he undertook research on interleukin-1 receptors and was the first to discover both the type II IL-1 receptor and the soluble IL-1 receptor. From 1991 to 1994 Dr. Horuk was in the Department of Protein Chemistry, Genentech, California. Here Dr. Horuk started a research program centered on chemokines and their receptors and was the first to discover that the Duffy Antigen, a portal of entry for the malarial parasite Plasmodium vivax, was also a chemokine receptor. Dr. Horuk joined Berlex BioSciences in 1994 and presently leads a major program on chemokine receptor research. Dr. Horuk is a member of the American Society of Biochemistry and Molecular Biology, the American Association of Immunologists, the Protein Society, the International Cytokine Society, and the American Association for the Advancement of Science. Dr. Horuk has presented numerous invited lectures at international and national meetings on chemokines and has published more than 80 research papers. His current research interests involve the role of chemokines in disease and the implementation of various therapeutic interventions.

Table of Contents

The Role of Interleuken-8 in Inflammatory Diseases. Structure-Function Relationships of IL-8 and Its Two Neutrophil Receptors: IL-8-RA and IL-8-RB. Three-Dimensional Structures of the Chemokine Family. Melanoma Growth Stimulatory Activity: Physiology, Biology, Structure/Function, and Role in Disease. The Duffy Antigen Receptor for Chemokines. Biology, Biochemistry, and Pathophysiology of the RANTES Chemokine. The Monocyte Chemoattractant Protein Family. The Macrophage Inflammatory Protein Family. C-C Chemokine Receptors. Chemotactic Factor Receptors and Signal Transduction. Arachidonic Acid-Derived Bioactive Lipids and Their Role in Human Disease States. The N-Formylpeptide Chemotactic Receptor. Mechanism of Chemokine-Induced Leukocyte Adhesion and Emigration. Viral Chemokine Receptors. Chemokine Receptors in the Brain: Hierarchical Expression by Subsets of Neurons. Index.

Backcover Copy

Editorial Reviews

2 Stars from Doody

This book is an edited collection of monographs pertaining to the field of immunologic chemoattractants (chemokines), their receptors, and their biologic functions. Each chapter is written by authors known to be expert in this scientific area. The purpose of the book is to provide insight into the complex area of immune chemokine function. The information in the book is highly selective and sometimes lacking in general information and overviews. The book will be most useful to readers who already have some knowledge of this field and wish to gain a more detailed understanding of a specific topic that is included in this text. The book is directed at immunologists and clinicians with an interest in inflammatory diseases. In many chapters, the material is extremely detailed, and thus will appeal primarily to scientists who have a strong interest in this particular field of immunology. The book contains a large amount of information regarding the molecular structure of chemokines and chemokine receptors. The book contains many black-and-white illustrations, most of which depict chemokine molecular structure or sequence. The book also includes many excellent color drawings and histologic photomicrographs. The index is quite complete and will direct readers to specific topics of interest. This book provides selective but highly detailed information about inflammatory chemoattractants. Because the book does not provide overviews or basic information, the book is most suitable for scientists working directly in the field of immunologic chemokine structure and function, and it is unlikely to attract a larger audience. The book would be a valuable addition to libraries that supportscientists with specific research interests in this field.

Luisa A. DiPietro

Reviewer: Luisa A. DiPietro, DDS, PhD (Loyola University Medical Center)
Description: This book is an edited collection of monographs pertaining to the field of immunologic chemoattractants (chemokines), their receptors, and their biologic functions. Each chapter is written by authors known to be expert in this scientific area.
Purpose: The purpose of the book is to provide insight into the complex area of immune chemokine function. The information in the book is highly selective and sometimes lacking in general information and overviews. The book will be most useful to readers who already have some knowledge of this field and wish to gain a more detailed understanding of a specific topic that is included in this text.
Audience: The book is directed at immunologists and clinicians with an interest in inflammatory diseases. In many chapters, the material is extremely detailed, and thus will appeal primarily to scientists who have a strong interest in this particular field of immunology. The book contains a large amount of information regarding the molecular structure of chemokines and chemokine receptors.
Features: The book contains many black-and-white illustrations, most of which depict chemokine molecular structure or sequence. The book also includes many excellent color drawings and histologic photomicrographs. The index is quite complete and will direct readers to specific topics of interest.
Assessment: This book provides selective but highly detailed information about inflammatory chemoattractants. Because the book does not provide overviews or basic information, the book is most suitable for scientists working directly in the field of immunologic chemokine structure and function, and it is unlikely to attract a larger audience. The book would be a valuable addition to libraries that support scientists with specific research interests in this field.

Doody's Review Service