Cell Biology of Trauma / Edition 1

by John J. Lemasters, Constance Oliver

Overview

This unique book presents an approach to viewing trauma. It examines the cellular consequences of trauma at a molecular level and provides new insights into the treatment of traumatic injury, based on cellular responses. The current of trauma research is reviewed, previously unpublished information on the topic is presented, and research directions are included.

Product Details

ISBN-13:	9780849324536
Publisher:	Taylor & Francis
Publication date:	03/06/1995
Edition description:	New Edition
Pages:	384
Sales rank:	532,309
Product dimensions:	6.00(w) x 9.00(h) x (d)

About the Author

John J. Lemasters, M.D., Ph.D., is Professor of Cell Biology and Anatomy and Member of the Curriculum in Toxicology at the University of North Carolina at Chapel Hill. Dr. Lemasters graduated in 1969 from Yale University, New Haven, Connecticut, with a B.A. degree in psychology (cum laude with honors) and obtained his M.D. degree and Ph.D. degree in anatomy and cell biology in 1975 from the Johns Hopkins University School of Medicine, Baltimore, Maryland. Dr. Lemasters is a member of the American Association for the Advancement of Science, the American Association for the Study of Liver Diseases, the American Association of Anatomists, the American Heart Association, Council on Circulation, the American Physiological Society, the American Society for Biochemistry and Molecular Biology, the Biophysical Society, the American Society for Cell Biology, the Microscopy Society of America, and the Society of Toxicology. Dr. Lemasters serves on the editorial boards of the American Journal of Physiology: Cell Physiology, Cell Calcium, and Hepatology. He has been the recipient of many research grants from the National Institutes of Health, the National Science Foundation, the American Heart Association, and the Office of Naval Research. Dr. Lemasters is the author of over 200 papers and has previously edited two books. His current major research interests relate to ischemia/reperfusion injury and organ preservation for transplantation surgery. Constance Oliver, Ph.D., is a Program Officer in the Biomedical Science and Technology Program at the Office of Naval Research (ONR), Arlington, Virginia. Prior to joining ONR she was a Research Biologist at the National Institute of Dental Research, the National Institutes of Health, Bethesda, Maryland. She received her B A. degree from Northwestern University, Evanston, Illinois, her M.S. from the University of Utah, Salt Lake City, Utah, and her Ph.D. from the University of Texas at Austin, Austin, Texas. Dr. Oliver has over twenty years of experience in the field of cell biology. Her research has focused on structure-function relationships in the secretory pathway in exocrine acinar cells and in mast cells J She has examined packaging of secretory proteins and formation of secretory granules, membrane trafficking and signal transduction mechanisms in these cells. Currently, Dr. Oliver is managing research programs in Biomedical Science and Technology. She has published extensively and has made numerous presentations at local, national, and international conferences, workshops, and symposia based on her own research. In addition, she has edited several books and conference proceedings and served on the editorial board of The Journal of Histochemistry and Cytochemistry. Dr. Oliver is a member of the American Society for Cell Biology, the Histochemical Society, the Microscopy Society of America, the American Association for the Advancement of Science, the Association for Women in Science, and the Chesapeake Society of Electron Microscopy. In addition, she was elected to membership in Sigma Xi, an honorary academic society, named an Outstanding Young Woman of America, 1977, and received a Gold Medal from Tokyo Dental College, 1984.

Table of Contents

MECHANISMS OF LETHAL CELL INJURY — Chapter 1 — Models of Toxicity Screening Using Cultured Cells Roberta L. Grant and Daniel Acosta, Jr. — Chapter 2 — Apoptosis: Cellular Signaling and Molecular Mechanisms /Rosemary B. Evans and John A. Cidlowski — Chapter 3 — Role of Mitochondrial Injury during Oxidative Injury to Hepatocytes: Evidence of a Mitochondrial Permeability Transition by Laser Scanning Confocal Microscopy Anna-Liisa Nieminen, Roberto Imberti, Alice K. Saylor, Samuel A. Tesfai, Brian Herman, and John J. Lemasters — CYTOPROTECTIVE STRATEGIES — Chapter 4 — Glycine Cytoprotection and Inhibition of Nonlysosomal Calcium-Dependent Proteolysis during Anoxic Injury of Rat Hepatocytes /J. Christopher Nichols, Rolland C. Dickson, Steven F. Bronk, and Gregory J. Gores — Chapter 5 — Di-Calciphor-Dependent Protection against Cell Death due to Mitochondrial Failure /Dean P. Jones — Chapter 6 — Role of the Mitochondrial ATPase Inhibitor, IF1? in Cytoprotection during Ischemia in Slow and Fast Heart-Rate Hearts William Rouslin and Charles W. Broge — Chapter 7 — The Discovery and Pharmacology of Tirilazad Mesylate John M. McCall — Chapter 8 — The Role of Neutrophils and Reactive Oxygen Metabolites in Reperfusion Injury Barbara J. Zimmerman and D. Neil Granger — Chapter 9 — The Inflammatory Response after Hepatic Ischemia Reperfusion /Hartmut Jaeschke — Chapter 10 — The pH Paradox in Reperfusion Injury to Heart Cells John J. Lemasters, John M. Bond, Ian S. Harper, Enrique Chacon, Hisayuki Ohata, Brian Herman, and Wayne E. Cascio — Chapter 11 — Pathophysiology of Spinal Cord Injury in a Rat Model of Decompression Sickness Louis Marzella — STRESS RESPONSE AND WOUND HEALING Chapter 12 — The Stress Response and Stress Proteins Martin E. Feder, Dawn A. Parsell, and Susan L. Lindquist — Chapter 13 — Cross Talk between Heat Shock and Oxidative Stress Inducible Genes during Myocardial Adaptation to Ischemia /Dipak K. Das and Nilanjana Maulik — Chapter 14 — Alteration in Cell Cycle Control Factors and the Induction of Oxygen-Regulated Proteins by Hypoxic Stress Harold C. Smith, Robert L. Howell, and John W. Ludlow — Chapter 15 — Stress Proteins in Renal Ischemia /Shirley Hilden — Chapter 16 — Human Keratinocyte Migration Involves Extracellular Matrix and Soluble Factors David T. Woodley, John D. Chen, Elizabeth Shim, Janice P. Kim, Jean-Christophe Lapiere, and Christina Peavey — Chapter 17 — Endothelial Cell Signaling during Wound Healing /Lewis H. Romer — PRESERVATION OF CELLS AND ORGANS Chapter 18 — Development and Optimization of Preservation Solutions James H. Southard — Chapter 19 — Hypoxia, Free Radicals, and Reperfusion Injury Following Cold Storage and Reperfusion of Livers for Transplantation Ronald G. Thurman, Wenshi Gao, Henry D. Connor, Sigrid Bachmann, Robert T. Currin, Ronald P. Mason, and John J. Lemasters — Chapter 20 — Cellular Injury Associated with Organ Cryopreservation: Chemical Toxicity and Cooling Injury Gregory M. Fahy, Carla da Mouta, Latchezar Tsonev, Bijan S. Khirabadi, Patrick Mehl, and Harold T. Meryman — Index.

Editorial Reviews

Reviewer: Elizabeth J. Kovacs, PhD (Loyola University Medical Center)
Description: This interesting new book on the cell biology of trauma gives a general overview of the current research being conducted in the field. An emphasis is placed on studies at the cellular level in the organ systems that are critically involved in the response to injury.
Purpose: The purpose of the book is to give an overview of how organisms respond to trauma at the cellular level in key organ systems. It is a useful resource for basic scientists and clinicians entering the field of the cell biology of trauma as well as for those who want to catch up on what is going on in areas tangential to their research.
Audience: The targeted audience for the book is basic scientists and clinicians interested in the cell biology of trauma.
Features: The book includes numerous tables and figures containing data from published and unpublished work from many of the top investigators in the field. The figures and tables are clear and to the point. There are just a few diagrams to summarize some of the more complicated cascades of events that take place in the response of organs to injury.
Assessment: This is a useful book for basic scientists and clinicians interested in the field of the cell biology of trauma. It provides an overview of the systems critically involved in the organisms' response to injury.

Doody's Review Service

3 Stars from Doody

This interesting new book on the cell biology of trauma gives a general overview of the current research being conducted in the field. An emphasis is placed on studies at the cellular level in the organ systems that are critically involved in the response to injury. The purpose of the book is to give an overview of how organisms respond to trauma at the cellular level in key organ systems. It is a useful resource for basic scientists and clinicians entering the field of the cell biology of trauma as well as for those who want to catch up on what is going on in areas tangential to their research. The targeted audience for the book is basic scientists and clinicians interested in the cell biology of trauma. The book includes numerous tables and figures containing data from published and unpublished work from many of the top investigators in the field. The figures and tables are clear and to the point. There are just a few diagrams to summarize some of the more complicated cascades of events that take place in the response of organs to injury. This is a useful book for basic scientists and clinicians interested in the field of the cell biology of trauma. It provides an overview of the systems critically involved in the organisms' response to injury.

Elizabeth J. Kovacs