Cell and Molecular Biology of Endometrial Carcinoma / Edition 1

by H. Kuramoto, M. Nishida

Overview

The 15th International Symposium of the Japan Human Cell Society on Cell and Molecular Biology of Endometrial Carcinoma brought together leading researchers from Japan and around the world. The papers collected here are the work of twenty-two leaders in their field and are organized in ten major categories. The first section, in vitro experimental systems, takes up the pioneering work by Kuramoto in 1968 and Nishida in 1980 in establishing, respectively, the HEC-1 and hormone-responsive endometrial carcinoma cell lines. Other topics include apoptosis, proliferation, and growth factors; cell cycle regulators; signaling pathways; angiogenesis; carcinogenesis; hormones and hormone receptors; genes and gene expression; endometrial receptivity; and chemo-resistance and -sensitivity. Presenting the latest work in the cell and molecular biology of endometrial carcinoma, this volume is a valuable resource for gynecologists, pathologists, and molecular biologists.

Product Details

ISBN-13:	9784431679776
Publisher:	Springer Japan
Publication date:	10/09/2012
Edition description:	Softcover reprint of the original 1st ed. 2003
Pages:	319
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

1 In Vitro Experimental Systems.- HEC-l Cells: Establishment of an In Vitro Experimental System in Endometrial Carcinoma.- Ishikawa Cells: Opening of In Vitro Hormone Research on Endometrial Carcinoma.- 2 Apoptosis, Proliferation, and Growth Factors.- Endometrial Stress Neuropeptides: Paracrine Effects on Cell Proliferation and Apoptosis.- Effect of Hepayte Growth Factor on the Expression of Matrix Metalloproteinases in the Invasion of Endometrial Cancer Cells in a Three-Dimensional Coculture System.- 3 Cell Cycle Regulators.- Involvement of Cell Cycle Regulators in Steroid Hormone-Induced Growth of Endometrial Carcinoma.- Expression of Cell Cycle Regulators in Endometrial Adenocarcinoma.- 4 Signaling Pathways.- Estrogen Receptor Signaling and Crosstalk with the Ah Receptor in Endometrial Cancer Cells.- Expression of Cyclooxygenase (COX)-2 in Human Endometrial Adenocarcinoma Cell Line HEC-1B: An In Vitro Model of the Expression of COX-2 by Platelet-Activating Factor, Human Chorionic Gonadotropin and Prostaglandin E2, and the Possible Signaling Pathways Involved.- Inhibition of AKT Oncogenic Pathway in Endometrial Cancer Cells.- 5 Angiogenesis.- A New Paradigm for Vascular Endothelial Cell Growth Factor Receptor Signaling in Adult Endothelium.- Sex Steroid-Dependent and -Independent Angiogenesis in Uterine Endometrial Cancers.- 6 Carcinogenesis.- Inhibitory Effects of Phytoestrogens and Related Herbal Extracts on Mouse Endometrial Carcinogenesis: A Review.- 7 Hormones and Hormone Receptors.- Role of Glycoprotein Hormones in Endometrial Cancer.- Contribution of Estrogen Receptor-? and Progesterone Receptor-B to Oncogenic K-Ras-Mediated NIH3T3 Cell Transformation.- 8 Genes and Gene Expression.- Regulation of Gene Expression in Endometrial Cancer Cells: Role of Extracellular Matrix in Mihondrial Gene Expression.- Role of hMLHl Gene Hypermethylation in Endometrial Carcinogenesis.- Molecular Genetic Profiles of Serous and Endometrioid Endometrial Cancers, Genes Downregulated in Endometrial Cancers, and the Role of Epigenetics.- Biological Implications of Survivin Gene Expression in the Development of Endometriosis and Endometrial Carcinoma.- 9 Endometrial Receptivity.- Endometrial Cancer Cells as Models to Study Uterine Receptivity.- 10 Chemo-resistance and -sensitivity.- Steroid and Xenobiotic Receptor (SXR) is a Key System for the Acquisition of cis-Platinum Resistance in Endometrial Cancer Cells.- Relationship Between HER-2/neu Gene Status and Chemosensitivity of Human Endometrial Cancer Cell Lines.- 313.

Editorial Reviews

3 Stars from Doody

Reviewer: I-Tien Yeh, M.D.(University of Texas Health Sciences Center at San Antonio)
Description: This text is a publication of the proceedings from the 15th International Symposium of the Japan Human Cell Society entitled "Cell and Molecular Biology of Endometrial Carcinoma", held in Tokyo on August 30-31, 2002.
Purpose: The editors' intent is to disseminate information on various aspects of research on endometrial carcinoma cell lines. This is a rather limited field, but the book does meet the objectives.
Audience: This book is appropriate for researchers with specific interest in in vitro culture systems for endometrial carcinoma. The two editors were the first to establish an in vitro cell line of endometrial carcinoma (HEC-1, 1968, Kuramoto) and a hormone-responsive endometrial cell line (Ishikawa, 1980, Nishida). The text also includes contributions from other Japanese and international investigators.
Features: There are 10 parts in the book, including an introductory part on in vitro experimental systems, followed by parts on the following topics: apoptosis, proliferation and growth factors; cell cycle regulators; signaling pathways; angiogenesis; carcinogenesis; hormones and hormone receptors; genes and gene expression; endometrial receptivity; and chemo-resistance and chemo-sensitivity. Individual sections within the parts are highly variable; some have detailed methods, others are reviews. Illustrations are in black and white. Most tables and graphs are helpful, but some of the photomicrographs appear a bit fuzzy.
Assessment: Cell and Molecular Biology of Endometrial Carcinoma gives a snapshot in time on the state of the art endometrial carcinoma research using in vitro systems. It may be useful to specialized researchers, including researchers in other cancers, but is probably not very useful to the clinician or general pathologist.

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