Cartilage Surgery and Future Perspectives

by Christian Hendrich (Editor), Ulrich Nöth (Editor), Jochen Eulert (Editor)

Overview

Tissue engineering as a technology and as a therapeutic has captured worldwide attention and commitmentbecause it has such potential in the care of humanity. Because we are not as yet able to craft robust three­ dimensional vascular and ductal structures to support the development of complex parenchymal organs, the initial focus of the field has been on thin tissues that can be nourished by diffusion alone.The best example of this class is cartilage. Thought by some to be a relatively simple tissue in the early days of tissue engineering, deep study of this tissue has shown it to manifest great complexity.Yearsof experimental and clinical effort have begun to untangle the clues that will allow us to reproducibly characterize, gener­ ate and clinically apply engineered cartilage with positive effects.World­ wide researchers and clinicians are intently focused on this goal and it has come time to step back and make a good assessment of our progress.

Product Details

ISBN-13:	9783642190087
Publisher:	Springer-Verlag New York, LLC
Publication date:	12/06/2012
Sold by:	Barnes & Noble
Format:	eBook
File size:	3 MB

Table of Contents

I: Basics.- 1 Anatomy and Biochemistry of Articular Cartilage.- 2 Cartilage Injury and Repair.- II: Clinical Results.- 3 Autologous Chondrocyte Transplantation (ACT) — Long-Term Results.- 4 EURACT Study: A 24-Month Follow-up Multicenter Study of 84 Knees Treated with Autologous Chondrocyte Transplantation (ACT).- 5 Clinical Results of Autologous Chondrocyte Transplantation (ACT) Using a Collagen Membrane.- 6 Treatment of Chondral Defects by Matrix-Guided Autologous Chondrocyte Implantation (MACI).- 7 Transplantation of Osteochondral Autografts.- III: Tissue Engineering.- 8 Engineering Cartilage Structures.- IV: Biomaterials.- 9 Homogeneously Cross-Linked Scaffolds Based on Clinical-Grade Alginate for Transplantation and Tissue Engineering.- 10 Collagen and Hyaluronic Acid.- 11 Biodegradable Polymers.- 12 Photo-oxidized Osteochondral Transplants.- V: Cells for Cartilage Repair.- 13 Chondrocytes.- 14 Quality Assurance of Autologous Chondrocyte Transplantation (ACT).- 15 Human Mesenchymal Stem Cells: Isolation, Characterization and Chondrogenic Differentiation.- VI: Experimental in Vivo Results.- 16 Chondrocytes and Polymer Fleeces.- 17 Chondrocytes and Fibrin Glue.- 18 Chondrocytes and Collagen Gels.- 19 Fabrication of Cartilage-Polymer Constructs for Articular Cartilage Repair.- 20 Differentiation of Human and Murine Chondrogenic Cells Encapsulated in Ultra-High Viscosity Alginate.- VII: Future Perspectives.- 21 Skeletal Tissue Engineering in Cartilage Replacement: Future Perspectives and the New Age of Regenerative Medicine.

Editorial Reviews

3 Stars from Doody

Reviewer: Mark R Hutchinson, MD (University of Illinois at Chicago College of Medicine)
Description: This is an amazingly concise book which in 200 pages takes on the challenge of stepping back to review the progress made and assess the future work necessary on cartilage surgery from anatomy, to bioengineering new scaffolds, to optimizing regeneration of hyaline cartilage tissue.
Purpose: In creating this book, the authors have accomplished their goals by providing an overview of the field of cartilage surgery as a whole, providing a primer on cell biology, reviewing the raw materials that have been classically used, and outlining new directions including the emerging role of mesenchymal cell research. These are valuable objectives to a select audience and the authors have accomplished their goal.
Audience: Orthopedic residents, cartilage researchers, and orthopedic surgeons who demand a fundamental knowledge regarding the techniques that they use will find this a valuable and concise read. Due to the advanced nature of the research, the data on new trends of bioengineering and mesenchymal cell research will be outdated in time. Nonetheless, this book may be the quickest, most in-depth review and update on the concepts of cartilage surgery. The authors are primarily a collection of German and other European authors who have been on the cutting edge of this research.
Features: The book walks through some basic cartilage understanding of anatomy and injury repair and continues through clinical results and concepts of tissue engineering, biomaterials, and advanced experimental directions including mesenchymal cell research. Each chapter is concise and easy to read with excellent quality color photos.
Assessment: The advantage of this book is that it is amazingly concise for addressing such a complex topic. It is worthwhile reading for those wanting to know that status of cartilage repair surgery. The disadvantage of this book is that it will be outdated in time with the advances of new techniques and new developments in science. The application audience, surgeons actually doing this surgery, is relatively small.

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