Cardiac Energetics: From Emax to Pressure-Volume Area / Edition 1

by Martin M. LeWinter, Hiroyuki Suga, Matthew W. Watkins

Overview

Most of the progress in cardiac energetics in recent years has been spurred by the pressure-volume area concept, the natural extension into energetics of earlier pioneering work delineating the time-varying elastance framework for ventricular contraction. The book draws together a broad spectrum of researchers - basic, applied and clinical - having a shared interest in the energetics of cardiac muscle and ventricle, providing an overview of the current state of the art.

Product Details

ISBN-13:	9780792337218
Publisher:	Springer US
Publication date:	10/31/1995
Series:	Developments in Cardiovascular Medicine , #177
Edition description:	1995
Pages:	240
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

1. Energy Costs of PVA and Emax: Constancy and Variability.- 2. Kinetic Property of Cardiac Myosin In Vitro1.- 3. Thin Filament Regulation and Cardiac Energetics.- 4. Explaining Load-Dependent Ventricular Performance and Energetics Based on a Model of E-C Coupling.- 5. Cardiac Contractions, PVA and Energetic Considerations Determined from a Cardiac Muscle Crossbridge Model.- 6. Normalization of Emax and PVA.- 7. Observations on the Relation of PVA and MVO2 in Closed Chest Dogs.- 8. Regional Myocardial Contraction Coupled with Energetics.- 9. Energetics During Ventricular Fibrillation.- 10. Influence of Preload on Non-Mechanical VO2 Assessed with 2,3-Butanedione Monoxime.- 11. Emax and Myocardial Microcirculation.- 12. Efficiency of Ventricular-Arterial Coupling and Baroreflex Regulation of Blood Pressure.- 13. Ventriculo-Arterial Load Matching of Failing Hearts.- 14. Calcium Signaling and Pharmacology of Cardiotonic Agents.- 15. Effect of Inotropic Agents on Mechanoenergetics in Human Diseased Heart.- 16. Effects of Various Inotropic Agents on the Relation Between Ventriculoarterial Coupling and Myocardial Energetics in Patients with Idiopathic Dilated Cardiomyopathy.

Editorial Reviews

Reviewer: Richard L. Clancy, PhD (University of Kansas Medical Center)
Description: This book consists of 16 chapters addressing the following aspects of cardiac muscle energetics: (1) contractility and the pressure volume area; (2) excitation-contraction coupling; and (3) inotropic agents in diseased hearts. Each chapter is a synopsis of a presentation at a workshop held in 1994.
Purpose: The purpose is to provide an overview of recent developments in the understanding of the energetics of cardiac muscle contraction. To fulfill this objective, research scientists contributed chapters related to their particular area of cardiac energetics research. This is an important objective because cardiac arrhythmias and impaired ventricular pump function are frequently a result of an inequality between cardiac energy demands and energy supply.
Audience: The chapters are written primarily for scientists and cardiologists who are actively engaged in cardiac energetics research. The contributors of the chapters are established investigators in the area of cardiac energetics.
Features: Because each chapter is written by a different group of scientists, there is little commonality in writing style and illustrations. Most illustrations are constructed in the format for publication in a peer-reviewed journal. The authors provide a relatively extensive index.
Assessment: This book is an outcome of a workshop held on this topic. It appears each chapter is a synopsis of the participants' presentations. Consequently, the chapters are most useful to scientists actively engaged in cardiac energetics research. Persons not actively engaged will find some chapters difficult because of the mathematical emphasis. This book would have been of use to a broader group of scientist had the authors included a background chapter and a chapter summarizing the significance of the findings of the contributors. The significance of the subject justifies biomedical libraries purchasing this book.

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