Bone Marrow Pathology

by Barbara J. Bain, David M. Clark, Bridget S. Wilkins, Vishakha Sovani

Overview

Bone Marrow Pathology has been extensively revised to reflect the significant advances which have occurred in the application of cytogenetics and in particular, molecular genetics in the diagnosis, classification and understanding of haematological disorders. This comprehensive book not only provides information on all common disease entities, but also covers rare disorders in which bone marrow examination is useful. It is designed as a practical resource with "problems and pitfalls" highlighted throughout to aid laboratory diagnosis.

Product Details

ISBN-13:	9781394244812
Publisher:	Wiley
Publication date:	03/17/2025
Edition description:	6th ed.
Pages:	960
Product dimensions:	6.50(w) x 1.50(h) x 9.50(d)

About the Author

Barbara J. Bain, MBBS, FRACP, FRCPath, is Professor of Diagnostic Haematology, St Mary's Hospital Campus, Imperial College Faculty of Medicine, and Honorary Consultant Haematologist, St Mary's Hospital, London, UK.

David M. Clark MD, MRCP (UK), FRCPath, is Consultant Haematopathologist, Nottingham University Hospitals NHS Trust, Nottingham and Honorary Clinical Senior Lecturer, Imperial College London.

Bridget S. Wilkins DM, PhD, FRCPath, is Consultant Haematopathologist, Guy's and St Thomas' Hospitals NHS Foundation Trust, London and Hampshire Hospitals NHS Foundation Trust, Winchester, and Honorary Clinical Senior Lecturer, Imperial College London.

Table of Contents

Preface to the fifth edition vi

Acknowledgements vii

Abbreviations viii

1 The normal bone marrow 1

2 Special techniques applicable to bone marrow diagnosis 61

3 Infection and reactive changes 109

4 Acute myeloid leukaemia mixed phenotype acute leukaemia the myelodysplastic syndromes and histiocytic neoplasms 185

5 Myeloproliferative and myelodysplastic/myeloproliferative neoplasms and related conditions 267

6 Lymphoproliferative disorders 346

7 Plasma cell neoplasms 487

8 Disorders of erythropoiesis granulopoiesis and thrombopoiesis 537

9 Miscellaneous disorders 585

10 Metastatic and non‐haemopoietic tumours 645

11 Diseases of bone 685

Appendix 699

Index 709

What People are Saying About This

From the Publisher

'...of outstanding quality, this book should secure a place as a benchbook for students and practitioners of haematology and pathology alike'
Cytopathology

'This is certainly the best book so far on this subject. It should appeal to those who do not regularly report marrows, as marrow histology can be very challenging in this setting.'
Australian Journal of Medical Science

'I wholeheartedly recommend the book to trainees and practising pathologists, whether in haematology or in histopathology, and to a wider medical readership as a clear and informative text.'
Royal College of Pathologists Bulletin.

Editorial Reviews

Provides a practical guide to diagnosing bone marrow disease, including both hematological disease and more generalized pathological processes that may affect the bone marrow. Balancing cytological and histological assessment, and emphasizing the need for an integrated approach to diagnosis, places bone marrow diseases within the broader context of clinical and peripheral blood features. Explains what information can be wrung out of routine stains of bone marrow aspirates and of paraffin-embedded and plastic-embedded biopsy sections, as well as more specialized procedures such as immunocytochemistry and immunohistochemistry. Updated from the 1992 edition and augmented with more color illustrations, appendices of technical methods, and the REAL classification of lymphomas. A laboratory handbook and reference for trainees and practicing pathologists. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

"Bone Marrow Pathology is unique in that it avoids overlap with existing books of its kind and is thus a useful adjunct to information already available. Reasonably priced and of outstanding quality, this book should secure a place as a benchbook for students and practitioners of haematology and pathology alike." Cytopathology "This is certainly the best book so far on this subject. It should appeal to those who do not regularly report marrows, as marrow histiology can be very challenging in this setting." Australian Journal of Medical Science

From the Publisher