Biomolecular Crystallography: Principles, Practice, and Application to Structural Biology / Edition 1

Biomolecular Crystallography: Principles, Practice, and Application to Structural Biology / Edition 1

by Bernhard Rupp
ISBN-10:
0815340818
ISBN-13:
9780815340812
Pub. Date:
10/20/2009
Publisher:
Taylor & Francis
ISBN-10:
0815340818
ISBN-13:
9780815340812
Pub. Date:
10/20/2009
Publisher:
Taylor & Francis
Biomolecular Crystallography: Principles, Practice, and Application to Structural Biology / Edition 1

Biomolecular Crystallography: Principles, Practice, and Application to Structural Biology / Edition 1

by Bernhard Rupp

Hardcover

$170.0 Current price is , Original price is $170.0. You
$170.00 
  • SHIP THIS ITEM
    Temporarily Out of Stock Online
  • PICK UP IN STORE
    Check Availability at Nearby Stores
  • SHIP THIS ITEM

    Temporarily Out of Stock Online

    Please check back later for updated availability.

Temporarily Out of Stock Online


Overview

Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography. Deftly illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. It distills key concepts for understanding the practice and analysis of protein crystal structures and contains examples of biologically-relevant molecules, complexes, and drug target structures.

Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.


Product Details

ISBN-13: 9780815340812
Publisher: Taylor & Francis
Publication date: 10/20/2009
Edition description: New Edition
Pages: 800
Product dimensions: 8.70(w) x 11.00(h) x 1.50(d)

About the Author

Bernhard Rupp is the CEO and founder of q.e.d. life science discoveries in California. Dr. Rupp established the protein drug target crystallography group at the University of California Lawrence Livermore National Laboratory in 1993 and expanded it into high throughput crystallization and structural genomics with focus on drug target structures and structure guided drug discovery. He was also a founding member of TB Structural Genomics Consortium. Dr. Rupp is a consultant for several US biotech ventures, universities, and instrument manufacturers. He is a member of the U.S. National Academy of Sciences Committee for Crystallography and NAS Keck Futures Initiatives panel. Dr. Rupp lectures regularly at NSF sponsored workshops on Biomolecular Crystallography and at the EMBO PEPC workshops on protein expression,

Table of Contents

PART I: FROM SEQUENCE TO CRYSTALS
1. Introduction: Preparing Your Study
2. Protein Structure
3. Protein Crystallization
4. Proteins for Crystallography

PART II: FUNDAMENTALS OF PROTEIN CRYSTALLOGRAPHY
5. Crystal Geometry
6. Diffraction Basics
7. Statistics and Probability in Crystallography

PART III: FROM CRYSTALS TO DATA
8. Instrumentation and Data Collection

PART IV: DETERMINING YOUR STRUCTURE
9. Reconstruction of Electron Density and the Phase Problem
10. Experimental Phasing
11. Non-Crystallographic Symmetry and Molecular Replacement
12. Model Building and Refinement

PART V: MAKING SENSE OF YOUR STRUCTURE
13. Structure Validation, Analysis, and Presentation

From the B&N Reads Blog

Customer Reviews