Biology of Sleep Substances / Edition 1

by Shojiro Inoue

Overview

All aspects of sleep sciences are included in this excellent resource text, with special reference to sleep substances and sleep modulators. The historical development of the theories of sleep are reviewed in conjunction with the technical problems. All candidate substances are overviewed as to their sites of presence, chemical nature, bioassay techniques, physiological and pharmacological effects. On the basis of a standardized methodology developed by the author, sleep-modulatory characteristics of some substances are compared and evaluated in quantitative terms. The sleep regulatory mechanisms, which are composed of complex neurohumoral subsystems, are analyzed from the results of recent neurophysiological and neuroendocrinological experiments. Furthermore, an evolutionary aspect of sleep substances is taken into consideration.
Chapters Highlight:
Techniques for isolation and evaluation
Prostaglandins
Paradoxical sleep factors
Sleep-promoting substances and nucleosides

Product Details

ISBN-13:	9780849348228
Publisher:	Taylor & Francis
Publication date:	03/31/1989
Pages:	216
Product dimensions:	7.00(w) x 10.00(h) x (d)

Table of Contents

Candidate Substances, Research Background, and Biological Roles. Techniques for Isolation and Evaluation. Delta-Sleep-Inducing Peptide and Its Derivatives. Sleep-Promoting Substance (SPS) and Nucleosides. Muramyl Peptides and Immunoreactive Substances. Prostaglandins. Paradoxical Sleep (PS) Factors. Other Sleep Modulators. Interactions of Sleep Substances. Evolutionary Aspects. Index.

Editorial Reviews

Here, Inoue (biocybernetics, and physiology, Tokyo Medical and Dental U.) incorporates past and present knowledge of putative sleep substances, (of which there are a large number) comparing several significant peptides including DSIP (delta-sleep-inducing peptide), muramyl, and prostaglandins. He considers the action of individual sleep substances and how they may be modified by various factors, including the time of day, nutritional conditions, the preceding state of vigilance (i.e., sleep deprivation, stress, insomnia, etc.), age, and the body and environmental temperatures. A thoughtful overview on the development of this field of science. Acidic paper. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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