B Cells in Immunity and Tolerance

by Ji-Yang Wang

Overview

This book contains twelve chapters contributed by prestigious international experts who are at the forefront of B cell research, and aims to provide a cutting-edge and comprehensive overview of all aspects of B cells, including B cell development, maturation and activation, germinal center reaction, memory and plasma cell differentiation, and antibody-mediated positive and negative regulation of humoral immune responses. There are also three chapters describing human diseases caused by B cell abnormalities, including primary antibody deficiencies, autoimmune diseases, and B cell malignancies. We hope that this book will become a standard and routine reference for both basic researchers and clinicians.

Product Details

ISBN-13:	9789811535314
Publisher:	Springer Nature Singapore
Publication date:	04/24/2020
Series:	Advances in Experimental Medicine and Biology , #1254
Edition description:	1st ed. 2020
Pages:	181
Product dimensions:	7.01(w) x 10.00(h) x (d)

About the Author

Dr. Ji-Yang Wang is a professor at Department of Immunology, School of Basic Medical Sciences, Fudan University, China. He was recruited to the 1000Talents Program of Shanghai in 2013. Prof. Wang’s research focuses on B cell development, activation and differentiation, and B cell-related diseases. He has published more than 100 articles on international journals in these fields.

Table of Contents

B cell development and maturation.- B cell receptor signalling.- Involvement of reactive oxygen species (ROS) in BCR signaling as a second messenger.- Germinal center reaction.- Memory B cells in local and systemic sites.- Regulation of plasma cell differentiation.- Regulation of humoral immune responses and B cell tolerance by the IgM Fc receptor.- Regulatory B cells.- Diversified IgA-bacteria interaction in gut homeostasis.- Primary antibody deficiencies.- B cell-mediated autoimmune diseases.- B cell lymphomas.

Editorial Reviews

Reviewer: Richard F Coico, MS, PhD (SUNY Downstate Health Sciences University)
Description: This book describes current knowledge of B cell development, activation, germinal center reaction, and memory. It also covers topics related to regulation of antibody responses and mechanisms of tolerance. Finally, chapters devoted to B cells and disease describe the wide range of abnormalities responsible for antibody deficiencies, humoral autoimmunity, and cancers such as lymphomas.
Purpose: The purpose is to describe B cell biology beginning with development and differentiation and segueing to requirements for B lymphocyte activation, regulation, class switching, affinity maturation, memory, and plasma cell formation. It also aims to provide current knowledge of B cells in disease including breakdown in mechanisms of tolerance leading to autoimmunity as well as deficiencies in B cell development responsible for certain immunodeficiency diseases. These are important objectives, which the book appropriately covers with clarity.
Audience: This book is mainly intended for biomedical and clinical scientists in the field of immunology. This is not an introductory resource for those interested in learning basic immunology with a focus on antibody responses. Graduate students and trainees specializing in immunology, rheumatology, and infectious diseases would also benefit from this resource. The contributors of the 12 chapters are qualified, credentialed experts.
Features: The book contains 12 chapters devoted to B cell biology and pathology. It presents a well-targeted selection of major contemporary topics critical to the understanding of humoral immunity and diseases caused by B cell abnormalities. The latter include disease-promoting abnormalities in B cell development/differentiation as well as central and peripheral tolerance. Understanding B cell-related pathophysiology requires a solid foundation in B cell physiology. A good example of the quality of coverage is provided in a chapter titled "Germinal Center Reaction," which describes the activation, regulation, and outcome of B cell receptor recognition of antigens leading to primary immune responses and, ultimately, class switching, affinity maturation, memory cell formation, and the generation of plasma cells. The book is a relatively short compendium of mini reviews of the topics included. The topics of B cell-mediated autoimmune diseases and B cell malignancies are somewhat minimally covered, although they highlight major causes of these diseases.
Assessment: This book provides an up-to-date summary of B cell physiology with detailed perspectives regarding genetic, molecular, and cellular elements responsible for humoral immunity. B cell abnormalities (e.g., deficiencies, autoimmunity, cancers) are essentially introduced in three separate chapters. There is a paucity of current books with similar objectives. Most current resources devoted to B cell biology and B cell-associated diseases are available in review articles (e.g., the Annual Review of Immunology) and books that may contain single chapters on the broad subject of B cells in immunity and tolerance.

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