Autophagy in Health and Disease: Potential Therapeutic Approaches

by Kursad Turksen

Overview

This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases.

The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing cliniciansand advanced graduate students.

Product Details

ISBN-13:	9783030074579
Publisher:	Springer International Publishing
Publication date:	12/26/2018
Series:	Stem Cell Biology and Regenerative Medicine
Edition description:	Softcover reprint of the original 1st ed. 2018
Pages:	177
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Kursad Turksen received his Ph.D. from the University of Toronto in Toronto, Canada in the area of osteoprogenitor biology and cell selection methodologies. He completed his postdoctoral training at the Howard Hughes Medical Institute, University of Chicago, in Chicago, Illinois, studying epidermal biology through use of genetically-altered mouse models. He joined the Ottawa Hospital Research Institute in Ottawa, Canada [previously known as the Loeb Research Institute] where he rose to the position of Senior Scientist in the Division of Regenerative Medicine. His research interests focus on stem cell biology, with a particular interest in the Claudin family of tight junction proteins and their role in epidermal lineage commitment and progression during development in health and disease. Dr. Turksen was, until recently, Editor in Chief of the Springer journal Stem Cell Reviews and Reports and currently serves as Series Editor for the Springer series Stem Cell Biology and Regenerative Medicine.

Table of Contents

Autophagy and Stem cells.- Fine-Tuning the Stem Cell Fate by Autophagy.- Role of Autophagy in Aging of Hematopoietic Stem Cells and Their Niche: Relevance in Clinical Transplantations and Regenerative Medicine.- Forkhead box O (FoxO) Transcription Factors in Autophagy, Metabolic Health, and Tissue Homeostasis.- The Role of mTOR in Osteoclasts.- Apoptotic Cell Clearance in Gut Tissue-Role of Intestinal Regeneration.- Autophagic Regulation of Cardiomyocyte Survival and Heart Regeneration.- The Role of Autophagy in Mesenchymal Stem Cell-Based Suppression of Immune Response.- Emerging Connections: Presynaptic Autophagy in Brain Aging and Neurodegenerative Diseases.- Virus and Autophagy: Enemies or Allies.- Cancer Stem Cells and Autophagy: Present Knowledge and Future Perspectives.

Editorial Reviews

Reviewer: Thomas Bodenstine, PhD (Midwestern University)
Description: This is a collection of independent articles on the many facets of autophagy with a strong emphasis on its relationship to stem cells. The offerings include organ and cell-type specific discussions in a manner that relates the material to normal and pathological settings.
Purpose: The book serves as an up-to-date resource on the role of autophagy in stem cells and it provides a review of research advances in this area with potential clinical applications.
Audience: Although the overall process and mechanisms of autophagy are described in many chapters, the book is best suited for readers with an initial understanding of autophagy and related pathways.
Features: The book covers an array of topics that provide perspective on the role of autophagy in normal cellular function. While many chapters focus on different types of stem cells in physiological processes, other chapters provide information about important regulatory mechanisms such as the mTOR pathway and FoxO transcription factors. The chapters include reviews of current research findings and provide comprehensive reference sections. Chapters are supplemented with both original and reproduced color figures.
Assessment: This is a useful supplement for those studying autophagy and provides important perspectives in basic and translational science. It summarizes the known roles of this process in human biology and provides a current outlook on how a better understanding of autophagy will lead to advances in many areas of medicine.

Doody's Review Service

This is a useful supplement for those studying autophagy and provides important perspectives in basic and translational science. It summarizes the known roles of this process in human biology and provides a current outlook on how a better understanding of autophagy will lead to advances in many areas of medicine.” (Thomas Bodenstine, Doody's Book Reviews, May 03, 2019)

From the Publisher