Anxiety Disorders: Pathophysiology and Pharmacological Treatment

by Gerard Emilien, Cecile Durlach, Ulla Lepola, Timothy Dinan

Overview

In this book, the discussion of the normal and pathological aspects of anxiety is critically examined. A chapter on the molecular basis of anxiety is included, outlining the potential of such approach in the discovery of novel effective pharmacological interventions. The face validity, predictability and usefulness of animal models in the design of valid new efficacious products are discussed. Separate chapters dedicated to each particular type of anxiety such as generalized anxiety disorder, social phobia, posttraumatic stress disorder, panic and obsessive-compulive disorder are included. This book should be of benefit to psychiatrists, clinical psychologists, general practitioners, nurses, students and all those engaged in neuropsychiatric research.

Product Details

ISBN-13:	9783034894609
Publisher:	Birkhäuser Basel
Publication date:	11/05/2012
Edition description:	Softcover reprint of the original 1st ed. 2002
Pages:	298
Product dimensions:	7.01(w) x 10.00(h) x 0.03(d)

Table of Contents

1:Normal and pathological anxiety.- 1 What is anxiety?.- 2 Relevance of laboratory research on anxiety disorders.- 3 Genetic factors and brain imaging.- 4 Management.- 5 Discussion.- 2:Biological basis of anxiety and strategies for pharmacological innovation.- 1 Introduction.- 2 Neurobiology of anxiety disorders.- 3 Recent development and future anxiolytics.- 4 Discussion.- 3:Generalised anxiety disorder.- 1 Introduction.- 2 Diagnostic.- 3 The phenomenon of worry.- 4 Neurobiology.- 5 Physiopathology.- 6 Epidemiology and natural course.- 7 Treatment.- 8 Methodology for clinical investigation.- 9 Discussion.- 4:Social phobia.- 1 Introduction.- 2 Diagnosis and comorbidity.- 3 Pathophysiology.- 4 Treatments.- 5 Methodology of clinical investigations.- 6 Discussion.- 5:Panic disorder.- 1 Introduction.- 2 Diagnosis and aetiology.- 3 Pathophysiology.- 4 Treatments.- 5 Methodology for clinical investigation.- 6 Discussion.- 6:Obsessive-compulsive disorder.- 1 Introduction.- 2 Diagnostic.- 3 Physiopathology.- 4 Treatment.- 5 Methodology for clinical investigation.- 6 Discussion.- 7:Posttraumatic stress disorder.- 1 Introduction.- 2 Epidemiology.- 3 Comorbidity.- 4 Physiological and neurological abnormalities associated with PTSD.- 5 Cognitive dysfunction associated with PTSD.- 6 Treatment of PTSD.- 7 Discussion.- 8:Phobic disorders.- 1 Introduction.- 2 Epidemiology.- 3 Genetics.- 4 Treatment.- 5 Discussion.- 9:Laboratory models of anxiety.- 1 Introduction.- 2 Biological animal models.- 3 Behavioural animal models.- 4 Human models.- 5 Issues relevant to some non-benzodiazepine anxiolytics.- 6 Discussion.- 10:Discussion and perspectives.- Future perspectives.

Editorial Reviews

3 Stars from Doody

Reviewer: Lavinia L. Myers, MD (Rush University Medical Center)
Description: This is an interesting new book reviewing the spectrum of anxiety disorders, with particular focus on pathophysiology and treatment.
Purpose: The purpose is to provide a discussion of normal and pathological anxiety, as well as a detailed review of the major anxiety disorders. It includes a survey of current research, including animal models of anxiety, and discusses the usefulness and validity of this research for clinical practice. This is an important review of an area of great clinical interest. The book largely meets its overall objective.
Audience: This book is intended for psychiatrists, clinical psychologists, general practitioners, nurses, students, and others engaged in neuropsychiatric research, and will be useful for a more detailed review of the anxiety disorders. The authors are credible and knowledgeable in this field.
Features: The book contains numerous tables and charts throughout to illustrate the written material. These enhance the readability of the book. Each chapter lists numerous references, which are thorough and relevant.
Assessment: This is a thorough, useful book for practitioners and researchers as a comprehensive review of the current theories on etiology of anxiety disorders as well as the most recent research models. It also provides practical treatment guidelines in pharmacological, behavioral, and psychological modalities, citing evidence for the usefulness of each dicussed intervention. This book helps bring together the theoretical as well as practical aspects of understanding and treating anxiety disorders.

Doody's Review Service