Angiotensin Receptors / Edition 1

by J.M. Saavedra, P.B.M.W.M. Timmermans

Overview

From molecular biology to clinical applications of selective receptor blockade, the present volume compiles the latest advances of this emerging field. Of particular importance is the attention given to the newly discovered AT₂ receptors, and the physiology and pathophysiology of angiotensin receptor subtypes. The book will provide clinicians treating cardiovascular disease and hypertension with a clearer understanding of this therapeutically important and complicated hormone.

Product Details

ISBN-13:	9780306446917
Publisher:	Springer-Verlag New York, LLC
Publication date:	01/28/1994
Edition description:	New Edition
Pages:	438
Product dimensions:	6.00(w) x 9.00(h) x 1.13(d)

Table of Contents

Angiotensin II Receptor (T. Inagami et al.). Molecular Biology of Angiotensin II Receptors (B. Lassègue et al.). Defining Angiotensin Receptor Subtypes (A.T. Chiu et al.). Medicinal Chemistry of Angiotensin II Antagonists (W.J. Greenlee, R.W. Wexler). The Angiotensin II AT2 Receptor Subtype (M. de Gasparo et al.). Medicinal Chemistry of AT2 Receptors (J.J. Edmonds, J.C. Hodges). Pharmacology of AT2 Receptors (J.A. Keiser, R.L. Panek). Brain Angiotensin II Receptor Subtypes (J.M. Saavedra). Second Messengers for Brain Angiotensin Receptor Subtypes (F.M.J. Heemskerk, J.M. Saavedra). Angiotensin Receptor Subtypes and Cerebral Blood Flow (C. Strömberg et al.). Angiotensin II Receptor Subtypes and Growth (M. Viswanathan, J.M. Saavedra). Inhibiting Effects of Angiotensin II on Cardiovascular Hypertrophy in Experimental Hypertension (J.J. Morton). Inhibiting the Effects of Angiotensin on Cardiovascular Hypertrophy (K.P. Metsärinne et al.). 8 additional articles. Index.

Editorial Reviews

Compiles some of the most recent discoveries in the emerging field of angiotensin receptors, from their molecular biology to the clinical application of selective receptor blockade. The volume includes chapters on the molecular biology of the recently cloned AT1 receptors; the pharmacology and medicinal chemistry of the two main angiotensin receptor subtypes currently known, the AT1 and the AT2 subtypes; and a classification of receptor subtypes defined by ligand selectivity, biochemical receptor characteristics, and genetic analysis. Two new areas of interest receive particular attention: the newly discovered AT2 receptors and the brain angiotensin receptor subtypes. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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