Anesthetic Toxicity

by Susan A Rice (Editor)

Overview

This text is a source of information on the toxicity of anaesthetic agents. The editors define toxicity in a broad sense to mean an adverse effect, whether that effect is the result of pharmacological, toxicological, physiological, or other mechanisms. They bring together reviews by experts in the disciplines concerned - including biochemistry, genetics, and immunology - involved in current research on these adverse effects.; The initial chapters provide an understanding of the factors responsible for toxicity, and the ways in which the adverse effects of anaesthetics can be investigated. Subsequent chapters cover topics such as: hepatotoxicity; nephrotoxicity; malignant hyperthermia triggered by anaesthetics; pulmonary effects of anaesthesia; toxicity of local anaesthetic agents; toxicity of nitrous oxide; immunosuppression in the postoperative period; and reproductive and developmental toxicity of anaesthetics. Many of the contributors offer insights into the anaesthetics and their interactions, such as the immunological effects of anaesthesia and the impact of pharmacogenetics.

Product Details

ISBN-13:	9780781702027
Publisher:	Taylor & Francis
Publication date:	06/30/1994
Edition description:	New Edition
Pages:	306
Product dimensions:	8.25(w) x 11.00(h) x (d)

About the Author

Susan A Rice

Table of Contents

Anaesthetic Toxicity: An Overview, Susan A. Rice and Kevin J. Fish Animal Use in Toxicity Evaluation , Victor S. Lukas, Jr. Principles of Epidemiology for Evaluation of Anaesthetic Toxicity, Kristie L. Ebi Metabolism of the Volatile Anaesthetics, Lucy Waskell Hepatotoxicity of Halogenated Anaesthetics, Max T. Baker and Russell van Dyke Nephrotoxicity of Volatile Anaesthetic Agents, Kevin J. Fish The Toxicity of Local Anaesthetic Agents, Hal S. Feldman Toxicity of Nitrous Oxide, Donald D. Koblin Reproductive and Developmental Toxicity of Anaesthetics in Animals, Susan A. Rice Reproductive and Developmental Toxicity of Anaesthetics in Humans, Kristie L. Ebie and Susan A. Rice Pharmacogenetics and Anaesthetic Toxicity, Margaret Wood Malignant Hyperthermia Triggered by Anaesthetics, Marilyn Green Larach Immunosuppression in the Postoperative Period, Girish C. Moudgil Pulmonary Effects of Anaesthesia, Brian P. Kavanagh and Ronald G. Pearl Biomarkers of Anaesthetic Toxicity, C. Murray Ardie.

Editorial Reviews

Reviewer: Alicia Toledano, ScD (University of Chicago Pritzker School of Medicine)
Description: This is a thoughtfully compiled book presenting information on the background of anesthetic toxicity, review of familiar toxicities, and insights into anesthetic toxicities provided by collaborative research in several disciplines.
Purpose: The purpose is to bring together in a single volume a current summary of the knowledge of adverse effects of anesthetic agents, including factors affecting toxicity and methods for investigating adverse effects, common toxicities such as nephrotoxicity and hepatotoxicity, and contributions from immunology, pharmacogenetics, and other disciplines. This book is the first to be devoted entirely to the important subject of anesthetic toxicity in nearly 20 years, and as such, is much needed. The book succeeds in presenting a broad review of the topic.
Audience: This book is targeted to a variety of health professionals, including anesthesiologists and other clinicians practicing in the operating suites or intensive care units, or engaging in clinical and laboratory research, and other laboratory researchers. Readers will find it written at a level that is easily understandable. The authors contributing chapters include clinicians and researchers in several disciplines.
Features: An abundance of informative, high-quality figures, tables, and graphs add to the appeal of this book. Most chapters have numerous references, many quite recent. The table of contents and index are helpful in locating particular topics.
Assessment: This book is a useful reference, containing contributions from several disciplines, thereby providing an extensive review of current knowledge in anesthetic toxicity. The book also serves as an excellent starting point for more in-depth research on specific topics.

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