Androgens and Androgen Receptor: Mechanisms, Functions, and Clini Applications / Edition 1

by Chawnshang Chang

Overview

Androgen Receptors is the most comprehensive and up to date volume on the topic, including discussions of the basic mechanisms of androgen-androgen receptor actions, their roles in the androgen-related diseases, and their potential clinical applications.

Key topics covered include:

-The discovery and cloning of the androgen receptor;

-Androgen receptor coregulators;

-Androgen related genes and their consensus DNA response elements;

-Basic mechanism of action including functional analyses, cellular localization and phosphorylation studies;

-Cross-talk to other signal transduction systems;

-The recent connections of androgens to women's diseases, such as osteoporosis and ovarian cancer.

This book is of interest to students, basic scientists, and clinicians as both a study guide and reference of research in the androgen field. It could also be used as an advanced level text in endocrinology, urology, OBGYN, or oncology.

Product Details

ISBN-13:	9781402071881
Publisher:	Springer US
Publication date:	10/31/2002
Edition description:	2002
Pages:	503
Product dimensions:	6.10(w) x 9.25(h) x 0.04(d)

About the Author

Chawnshang Chang, Ph.D., is the George Hoyt Whipple Distinguished Professor at the University of Rochester.

Table of Contents

Preface. Editor. List of Contributors.1. Androgen Biosynthesis and Degradation; Bon-Chu Chung, Meng-Chun Hu. 2. Structural and Functional Analysis of the Androgen Receptor; C. Heinlein, Chawnshang Chang. 3. Signal Transduction Pathways Modulate Androgen. Receptor Transcriptional Activity; C. Heinlein, Chawnshang Chang. 4. Androgen Receptor Interacting Proteins Co-Activators and Co-Repressors; C. Heinlein, et al. 5. Nongenomic Androgen Action; C. Heinlein, Chawnshang Chang. 6. The role of 5alpha-Reductase in Prostate Disease and Male Pattern Baldness; J. Shimazaki. 7. Natural Products and Environmental Androgens/Antiandrogens; Ming-Hsien Wang, et al. 8. Androgens in Prostate Cancer and Benign Prostatic Hypoplasia; T. Brown. 9. The Expanded Poly-Q Length Within AR and AR Coregulator A1B1 And Their Clinical Implications; A. Hsing, et al. 10. Androgen Receptor with Expanded Poly-Q Length in SBMA (Kennedy Disease); Y. Kobayashi, G. Sobue. 11. Androgen Insensivity Syndrome (Testicular Feminization); H. Nawata, et al. 12. Androgens in Immunology and Autoimmune Diseases; N. Olsen, W. Kovacs. 13. Androgens in Penile Development, Penile Erection and Erectile Dysfunction; J. Chang, et al. 14. Androgens and the Androgen Receptor in Male Sex Development and Fertility; L. Collins, et al. 15. Androgens and Brain Function: Behavioral Perspectives; R. Handa, R. McGivern. 16. Androgens, Skeletal Homeostasis, and Osteoporosis; D. Vanderschueren, et al. 17. Androgens and Coronary Artery Disease; A. von Eckardstein, F. CW Wu. 18. Androgen Therapy in Nonendocrine Illnesses; D. Spratt. 19. Androgens and Androgen Receptor in Dermatology; S. Itami, et al. 20. Androgen Deficiency and Abnormality in Women; S. Davis, C. Jang. Index.