Table of Contents
List of contributors ix
Foreword xiii
Acknowledgements xv
Notes on authors xvii
Introduction 1Anna A. Battaglia
Section I: Neurobiology of pain: Recent advances 11
1 Anatomy of pain pathways 13Andrew J. Todd
2 Spinal plasticity of the nociceptive system: The role of central sensitisation in chronic pain states 35Alban Latrémolière
3 Symptoms and pathology in neuropathic pain 89Matthew Thakur and Stephen B. McMahon
4 Recent advances in neuroimmune interactions in neuropathic pain: The role of microglia 123Elizabeth A. Old, Louise S. C. Nicol and Marzia Malcangio
5 Genetics and epigenetics of pain 149Franziska Denk and Stephen B. McMahon
6 The cannabinoid system and its role in nociception 169Massimiliano Beltramo
7 EphB receptors and persistent pain 201Isabella Gavazzi
Section II: Pain in the brain 225
8 Brain imaging in experimental pain 227Massieh Moayedi and Tim V. Salomons
9 Placebo effects in pain 249Luana Colloca, Adam P. Horin and Damien Finniss
10 Psychology and pain 267Lance M. McCracken
Section III: Pain in the lifecycle and in nervous system disorders 281
11 Pain in neonates and infants 283Fiona Moultrie, Segzi Goksan, Ravi Poorun and Rebeccah Slater
12 How do people with autism spectrum disorders (ASD) experience pain? 295Cecile Rattaz, Amandine Dubois and Amaria Baghdadli
13 Pain and depression: The janus factor of human suffering 317Angela Iannitelli and Paola Tirassa
14 Pain in multiple sclerosis: From classification to treatment 345Claudio Solaro and Michele Messmer Uccelli
15 Pain perception in dementia 361Miriam Kunz and Stefan Lautenbacher
16 The role of cognitive impairment in the placebo and nocebo effects 373Martina Amanzio
17 An overview of pain in Parkinson’s disease 387Panagiotis Zis, Elisaveta Sokolov and Kallol Ray Chaudhuri
Appendix: Interviews with chronic pain patients 409
Index 413