Advances in Surgical Pathology: Colorectal Carcinoma and Tumors of the Vermiform Appendix

by Rhonda Yantiss

Overview

Advances in Surgical Pathology: Colorectal Carcinoma and Tumors of the Vermiform Appendix, a volume in the Advances in Surgical Pathology series, features chapters on current and impending changes in the field with an emphasis on practical issues, recent developments, and emerging concepts. Created as a quick review to be used during pathologic evaluation of cancer specimens from the lower gastrointestinal tract, this book contains the latest information regarding emerging endoscopic techniques that aid in tumor classification and staging, mechanisms of pathogenesis, and clinical management. It combines gross and microscopic images and user-friendly tables for quick reference with a succinct, comprehensive review of issues important to management of patients with colorectal carcinoma. Not only does it discuss the applied concern of cancer epidemiology and prevention, the book also covers pathological features of cancer precursors. Plus, an introduction to future diagnostic and treatment modalities, such as biomarker analysis, chemotherapeutic strategies, targeted molecular therapies, and aggressive multidisciplinary approaches to patients with advanced stage disease.

Product Details

ISBN-13:	9781469830421
Publisher:	Wolters Kluwer Health
Publication date:	09/05/2013
Series:	Advances in Surgical Pathology
Sold by:	Barnes & Noble
Format:	eBook
Pages:	336
File size:	76 MB
Note:	This product may take a few minutes to download.

Table of Contents

Series Overview v

Contributors vii

Preface ix

Section I Introduction

1 Embryology, Anatomy, and Normal Histology of the Colorectum and Appendix Debra Beneck 3

2 Epidemiology of Colorectal Adenocarcinoma Karen Curtin 9

3 Screening and Surveillance for Prevention of Colorectal Carcinoma Felice Schnoll-Sussman Amir Soumekh 21

Section II Cancer Precursors: Colorectal Polyps and Chronic Colitis

4 Epithelial Polyps and Inflammatory Bowel Disease-Related Dysplasia Nicole C. Panarelli 33

5 Hamartomatous Polyps and Polyposis Syndromes Rhonda K. Yantiss 57

Section III Pathologic Features of Colorectal Carcinoma

6 Handling of Colorectal Cancer Resection Specimens Rhonda K. Yantiss 83

7 Morphologic Classification of Colorectal Epithelial Tumors Rhonda K. Yantiss 101

8 Pathologic Staging Issues: Implementation of the TNM Staging System Rhonda K. Yantiss 120

9 Prognostically Important Features of Colorectal Carcinoma Rhonda K. Yantiss 139

10 Differential Diagnosis of Colorectal Carcinoma Rhonda K. Yantiss 165

Section IV Molecular Pathology of Colorectal Carcinoma

11 Molecular Mechanisms of Colorectal Carcinogenesis Jinru Shia Rhonda K. Yantiss 191

12 Practical Issues Related to Ancillary Testing of Colorectal Carcinoma Wade S. Samowitz 204

13 MicroRNA Expression in Colonic Adenocarcinoma Nicole C. Panarelli 219

14 Noninvasive Biomarkers and Early Detection of Colorectal Cancer Carl V. Crawford, Jr. Rhonda K. Yantiss 231

Section V Advances in the Management of Colorectal Carcinoma

15 Emerging Endoscopic Techniques in the Management of IBD-related Neoplasia Nicole C. Ponarelli Ellen J. Scherl Rhonda K. Yantiss 243

16 Targeted Therapies for the Treatment of Advanced Colorectal Carcinoma Allyson J. Ocean Romae Palmer Manish A. Shah 255

17 Surgical Management of Stage IV Colorectal Cancer Michael D. Kluger Set Yee Lee Daniel Cherqui 267

Section VI Neoplasms of the Vermiform Appendix

18 Endocrine Cell (Carcinoid) Tumors of the Vermiform Appendix Rhonda K. Yantiss 283

19 Appendiceal Mucinous Neoplasms and Pseudomyxoma Peritonei Joseph Misdraji 289

20 Nonmucinous Epithelial Tumors of the Appendix Rhonda K. Yantiss 301

Index 313

Editorial Reviews

Reviewer: Hongyan Dai, MD, PhD (University of Kansas Medical Center)
Description: Colorectal carcinoma is the fourth leading cause of cancer-related deaths in the U.S. This book describes new advances in the screening, diagnosis, molecular testing, and management of colorectal cancer and the neoplasms of the appendix.
Purpose: A succinct and comprehensive review of issues important to the management of patients with colorectal carcinoma, including early detection, cancer pathogenesis, and molecular testing for targeted therapy, etc. is urgently needed.
Audience: This book is intended for pathologists, pathology fellows, and residents who are practicing GI pathology. The contributors are experts in this field who have been actively involved in research into colorectal cancer.
Features: Various aspects of colorectal cancer are covered, including screening and surveillance, precursor lesions (polyps and chronic colitis), histopathological features, molecular mechanisms of carcinogenesis, and advances in management are covered, as are neoplasms of the vermiform appendix. The vast majority of the macroscopic and microscopic pictures are presented with great attention to detail. The text is succinct, easy to read, and to the point.
Assessment: This is a comprehensive review of the new advances in the field of colorectal cancer. The information is current, concise, and highly readable. It deserves a place on any pathologist's shelf.

Doody's Review Service