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Overview
Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Product Details
ISBN-13: | 9780128207420 |
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Publisher: | Elsevier Science |
Publication date: | 11/25/2020 |
Series: | Advances in Immunology , #148 |
Pages: | 160 |
Product dimensions: | 6.00(w) x 9.00(h) x (d) |
About the Author
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.
Read an Excerpt
This volume contains articles on a vast range of immunology topics and is therefore of interest to all immunologists.
Table of Contents
Contributors ix
T Cell Activation and the Cytoskeleton: You Can't Have One Without the Other Timothy S. Gomez Daniel D. Billadeau 1
Introduction 2
TCR Signaling Leading to Actin Cytoskeletal Remodeling 4
Cytoskeletal Control of IS Formation 18
Regulation of TCR-Mediated MTOC Polarization 28
F-Actin-Mediated Regulation of Integrins 31
Cytoskeletal Dynamics and Cell Migration 36
Conclusion 48
References 50
HLA Class II Transgenic Mice Mimic Human Inflamamtory Diseases Ashutosh K. Mangalam Govindarajan Rajagopalan Veena Taneja Chella S. David 65
Introduction 68
Expression and Function of HLA-DQ Transgenes in Mice 69
HLA-DQ Transgenic Mice as Models for Human Allergies 74
Expression and Function of HLA-DR Transgenic Mice 77
HLA Class II Transgenic Mice Identify the Same Determinants of M. Tuberculosis-Derived Proteins as Humans 84
Collagen-Induced Arthritis - Model for Human Rheumatoid Arthritis 86
Experimental Autoimmune Encephalomyelitis: A Model for Multiple Sclerosis 92
Spontaneous Models for Human Type I Diabetes 107
Experimental Autoimmune Myasthenia Gravis 111
HlA and Gluten Sensitivity-Celiac Disease and Dermatitis herpetiformis 113
Relapsing Polychondritis 116
Spontaneous Autoimmune Myocarditis 119
Experimental Autoimmune Thyroiditis (Adapted from Kong et al., 2007) 122
Experimental Autoimmune Uveitis (Adapted from Pennesi et al., 2003) 125
Bacterial Superantigens and Toxic Shock Syndrome 127
Concluding Remarks 132
References 133
Roles of Zinc and Zinc Signaling in Immunity: Zinc as an Intracellular Signaling Molecule Toshio Hirano Masaaki Murakami Toshiyuki Fukada Keigo Nishida Satoru Yamasaki Tomoyuki Suzuki 149
Introduction 150
Zn Homeostasis, Zn Transporters, and Metallothioneins in Health and Disease 152
Role of Zn in the Immune Response 157
Role of Zn in Mast Cells 162
Zn Signaling 164
Conclusion and Future Prospects 167
Acknowledgements 169
References 169
The SLAM and SAP Gene Families Control Innate and Adaptive Immune Responses Silvia Calpe Ninghai Wang Xavier Romero Scott B. Berger Arpad Lanyi Pablo Engel Cox Terhorst 177
Introduction 179
Structure, Ligands, and Expression of the SLAM-Family Receptors 182
The SLAM-Family Gene Isoforms and Polymorphisms and their Role in a Genetic Predisposition for Systemic Lupus Erythematosus 197
The SLAM-Associated Protein 201
The Protective Role of SAP in X-Linked Lympho-Proliferative Disease 207
The SAP-Related Single SH2-Domain Proteins EAT-2A and EAT-2B 213
The SLAM-Family Receptors in NK Cell Responses 214
The Role of the SLAM-Family in Lymphoid Cells 220
The Role of the SLAM-Family on Nonlymphoid Cells 228
Concluding Remarks 232
References 233
Conformational Plasticity and Navigation of Signaling Proteins in Antigen-Activated B Lymphocytes Niklas Engels Michael Engelke Jurgen Wienands 251
Introduction 253
A Minimal Signaling Kit Couples to Proximal Transducer Enzymes 254
Signal Initiation: BCR Clusters with an Open Conformation 255
SLP-65: A Gateway to Intracellular Signaling Pathways 259
Dynamic Regulation of the BCR-Triggered Ca[superscript 2+] Response 261
Mechanism and Function of BCR-Induced Ras Activation 266
Concluding Remarks 272
References 272
Index 283
Content of Recent Volumes 291
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* Now Available Online as part of the Life Sciences package via ScienceDirect* Highly respected review series with an impact factor in 2003 of 7.424 and ranked number 8/114
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