Advances in Immunology

by Frederick W. Alt

Overview

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Product Details

ISBN-13:	9780128207567
Publisher:	Elsevier Science
Publication date:	09/28/2020
Series:	Advances in Immunology , #147
Pages:	146
Product dimensions:	6.00(w) x 9.00(h) x (d)

About the Author

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

Read an Excerpt

This volume contains articles on a vast range of immunology topics and is therefore of interest to all immunologists.

Table of Contents

Contributors     ix
T Cell Activation and the Cytoskeleton: You Can't Have One Without the Other   Timothy S. Gomez   Daniel D. Billadeau     1
Introduction     2
TCR Signaling Leading to Actin Cytoskeletal Remodeling     4
Cytoskeletal Control of IS Formation     18
Regulation of TCR-Mediated MTOC Polarization     28
F-Actin-Mediated Regulation of Integrins     31
Cytoskeletal Dynamics and Cell Migration     36
Conclusion     48
References     50
HLA Class II Transgenic Mice Mimic Human Inflamamtory Diseases   Ashutosh K. Mangalam   Govindarajan Rajagopalan   Veena Taneja   Chella S. David     65
Introduction     68
Expression and Function of HLA-DQ Transgenes in Mice     69
HLA-DQ Transgenic Mice as Models for Human Allergies     74
Expression and Function of HLA-DR Transgenic Mice     77
HLA Class II Transgenic Mice Identify the Same Determinants of M. Tuberculosis-Derived Proteins as Humans     84
Collagen-Induced Arthritis - Model for Human Rheumatoid Arthritis     86
Experimental Autoimmune Encephalomyelitis: A Model for Multiple Sclerosis     92
Spontaneous Models for Human Type I Diabetes     107
Experimental Autoimmune Myasthenia Gravis     111
HlA and Gluten Sensitivity-Celiac Disease and Dermatitis herpetiformis     113
Relapsing Polychondritis     116
Spontaneous Autoimmune Myocarditis     119
Experimental Autoimmune Thyroiditis (Adapted from Kong et al., 2007)     122
Experimental Autoimmune Uveitis (Adapted from Pennesi et al., 2003)     125
Bacterial Superantigens and Toxic Shock Syndrome     127
Concluding Remarks     132
References     133
Roles of Zinc and Zinc Signaling in Immunity: Zinc as an Intracellular Signaling Molecule   Toshio Hirano   Masaaki Murakami   Toshiyuki Fukada   Keigo Nishida   Satoru Yamasaki   Tomoyuki Suzuki     149
Introduction     150
Zn Homeostasis, Zn Transporters, and Metallothioneins in Health and Disease     152
Role of Zn in the Immune Response     157
Role of Zn in Mast Cells     162
Zn Signaling     164
Conclusion and Future Prospects     167
Acknowledgements     169
References     169
The SLAM and SAP Gene Families Control Innate and Adaptive Immune Responses   Silvia Calpe   Ninghai Wang    Xavier Romero   Scott B. Berger   Arpad Lanyi   Pablo Engel   Cox Terhorst     177
Introduction     179
Structure, Ligands, and Expression of the SLAM-Family Receptors     182
The SLAM-Family Gene Isoforms and Polymorphisms and their Role in a Genetic Predisposition for Systemic Lupus Erythematosus     197
The SLAM-Associated Protein     201
The Protective Role of SAP in X-Linked Lympho-Proliferative Disease     207
The SAP-Related Single SH2-Domain Proteins EAT-2A and EAT-2B     213
The SLAM-Family Receptors in NK Cell Responses     214
The Role of the SLAM-Family in Lymphoid Cells     220
The Role of the SLAM-Family on Nonlymphoid Cells     228
Concluding Remarks     232
References     233
Conformational Plasticity and Navigation of Signaling Proteins in Antigen-Activated B Lymphocytes   Niklas Engels   Michael Engelke   Jurgen Wienands     251
Introduction     253
A Minimal Signaling Kit Couples to Proximal Transducer Enzymes     254
Signal Initiation: BCR Clusters with an Open Conformation     255
SLP-65: A Gateway to Intracellular Signaling Pathways     259
Dynamic Regulation of the BCR-Triggered Ca[superscript 2+] Response     261
Mechanism and Function of BCR-Induced Ras Activation     266
Concluding Remarks     272
References     272
Index     283
Content of Recent Volumes     291

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Long-running serial that continually publishes cutting-edge reviews on the latest advancements in the field of immunology

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"The series which all immunologists need." —The Pharmaceutical Journal"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." —Science"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." —Journal of Immunological Methods

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