Three years have passed since a man-made virus targeting O negative blood created a new divergent species of humans, the Colicians. Now, further attempts at genetic engineering have created a new virus, the Caiten Strain, which targets those with A negative blood. As more and more people are infected in a laboratory experiment gone out of control, Austin Rockwell and Miriam Lobner attempt to flee the experimentation and start a new life together. They both learn they must make personal sacrifices for a cause greater than themselves: to protect their friends and family, and to make the world safer and more peaceful for everyone.
A Negative continues the intriguing storyline introduced in Cassandra Lynn King's novel Parallels and its sequel, O Negative.
